Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 9/20 | 0.48 |
| ▸ | PDE3A | Q14432 | 9/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.48 |
| ▸ | PDE4A | P27815 | 6/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.48 |
| ▸ | CA1 | P00915 | 3/20 | 0.43 |
| ▸ | CA2 | P00918 | 3/20 | 0.43 |
| ▸ | ACHE | P22303 | 3/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NPY1R | P25929 | 1/20 | 0.39 |
| ▸ | NPY2R | P49146 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8306755 | 0.81 | MTNR1A (0.37) | PDE3BPDE3APDE4BPDE4APDE4C | |
| SCHEMBL8912023 | 0.78 | CA12 (0.49) | PDE3BPDE3APDE4BPDE4APDE4C | |
| SCHEMBL9414809 | 0.78 | PDE4B (0.35) | PDE3BPDE3APDE4BPDE4APDE4C | |
| SCHEMBL9414695 | 0.78 | PDE4B (0.35) | PDE3BPDE3APDE4BPDE4APDE4C | |
| SCHEMBL8911889 | 0.77 | CA12 (0.51) | PDE3BPDE3APDE4BPDE4APDE4C | |
| SCHEMBL8302599 | 0.76 | PDE3B (0.46) | PDE3BPDE3APDE4BPDE4APDE4C | |
| SCHEMBL9414700 | 0.76 | PDE3B (0.50) | PDE3BPDE3APDE4BPDE4APDE4C | |
| SCHEMBL8911986 | 0.75 | MAPT (0.42) | PDE3BPDE3APDE4BPDE4APDE4C | |
| SCHEMBL8307326 | 0.75 | HDAC8 (0.51) | PDE3BPDE3APDE4BPDE4APDE4C | |
| Iodide SCHEMBL8309296 | 0.75 | PDE3B (0.49) | PDE3BPDE3APDE4BPDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0579059-B1 | Pyridazinone derivatives and processes for preparing the same | TANABE SEIYAKU CO (JP) | 1999-05-12 | — | — | EP | disclosed |
| US-5739132-A | ENDOTHOXIN SHOCK; NEPHRITIS | TANABE SEIYAKU CO., LTD. (JP) | 1998-04-14 | — | — | US | disclosed |
| EP-0579059-A1 | Pyridazinone derivatives and processes for preparing the same | TANABE SEIYAKU CO., LTD. (JP) | 1994-01-19 | — | — | EP | disclosed |