Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 2/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.33 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 3/20 | 0.32 |
| ▸ | CA2 | P00918 | 3/20 | 0.32 |
| ▸ | ACHE | P22303 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | BRAF | P15056 | 3/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | RAF1 | P04049 | 1/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9414695 | 0.92 | PDE4B (0.35) | PDE4BPDE3APDE4APDE4CPDE4D | |
| SCHEMBL8304547 | 0.78 | PDE3B (0.48) | PDE4BPDE3APDE4APDE4CPDE4D | |
| SCHEMBL8714966 | 0.77 | MTNR1A (0.33) | PDE4BPDE3APDE4APDE4CPDE4D | |
| SCHEMBL8306755 | 0.76 | MTNR1A (0.37) | PDE4BPDE3APDE4APDE4CPDE4D | |
| SCHEMBL9414973 | 0.76 | SMN1; SMN2 (0.36) | PDE4BPDE3APDE4APDE4CPDE4D | |
| SCHEMBL8305010 | 0.75 | HDAC8 (0.43) | — | |
| SCHEMBL8717945 | 0.75 | PDE4B (0.33) | PDE4BPDE3APDE4APDE4CPDE4D | |
| SCHEMBL9414927 | 0.75 | PNMT (0.40) | CA1CA2PKMSMN1; SMN2 | |
| SCHEMBL9383997 | 0.74 | NR1H2 (0.35) | PDE3APDE3BCA1CA2ALDH1A1 | |
| SCHEMBL8718584 | 0.74 | NPC1 (0.41) | NPC1RAB9AMTNR1AMTNR1BCA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0579059-A1 | Pyridazinone derivatives and processes for preparing the same | TANABE SEIYAKU CO., LTD. (JP) | 1994-01-19 | — | — | EP | disclosed |