Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | FAAH | O00519 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.30 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.30 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.30 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
| ▸ | HTR2C | P28335 | 1/20 | 0.30 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.30 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL95838 | 0.82 | CYP2C19 (0.35) | HTTALDH1A1CYP2C9CYP2C19FAAH | |
| SCHEMBL9818286 | 0.82 | HTT (0.42) | HTTALDH1A1CYP2C9CYP2C19CA1 | |
| SCHEMBL1324773 | 0.80 | TSHR (0.42) | ALDH1A1CYP2C9CYP2C19FAAHCA1 | |
| SCHEMBL29456687 | 0.80 | TSHR (0.42) | ALDH1A1CYP2C9CYP2C19FAAHCA1 | |
| SCHEMBL20477576 | 0.80 | GABRA1 (0.41) | FAAHCA1CA2LMNACYP1A2 | |
| SCHEMBL27821006 | 0.79 | HTT (0.32) | HTTCYP2C9CYP2C19 | |
| SCHEMBL27598998 | 0.79 | PARP1 (0.38) | HTTALDH1A1CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL30657429 | 0.77 | GABRA1 (0.46) | HTTALDH1A1FAAHCA1CA2 | |
| SCHEMBL6314176 | 0.77 | GABRA1 (0.46) | HTTALDH1A1FAAHCA1CA2 | |
| SCHEMBL15239771 | 0.77 | TRPA1 (0.43) | HTTALDH1A1FAAHCA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0891339-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-01-20 | — | — | EP | disclosed |
| WO-1997036881-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-10-09 | — | — | WO | disclosed |