Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.36 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8305325 | 0.91 | AKR1A1 (0.47) | AKR1B1AKR1A1 | |
| SCHEMBL8303795 | 0.88 | AKR1B1 (0.48) | AKR1B1ALDH1A1RXFP1KDM4EMEN1 | |
| SCHEMBL8304777 | 0.82 | AKR1B1 (0.45) | AKR1B1ALDH1A1AKR1A1SMN1; SMN2HK1 | |
| SCHEMBL8308531 | 0.81 | AKR1A1 (0.48) | AKR1B1AKR1A1 | |
| SCHEMBL8303689 | 0.81 | KDM4E (0.40) | AKR1B1ALDH1A1RXFP1KDM4EMEN1 | |
| SCHEMBL8303442 | 0.80 | AKR1B1 (0.49) | AKR1B1ALDH1A1RXFP1KDM4EMEN1 | |
| SCHEMBL8304398 | 0.80 | AKR1A1 (0.47) | AKR1B1AKR1A1 | |
| SCHEMBL8307547 | 0.77 | AKR1B1 (0.53) | AKR1B1AKR1A1 | |
| SCHEMBL8304753 | 0.74 | AKR1B1 (0.51) | AKR1B1AKR1A1 | |
| SCHEMBL8308022 | 0.74 | AKR1B1 (0.42) | AKR1B1ALDH1A1RXFP1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0633261-B1 | QUINOLINE-3-ACETIC ACID DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND USE THEREOF | YOSHITOMI PHARMACEUTICAL (JP) | 1999-04-21 | — | — | EP | disclosed |
| US-5543420-A | ALDOSE REDUCTASE INHIBITORS; ANTIDIABETIC AGENTS; PREVENTION OF ACCUMULATION OF SORBITOL AND GALACTITOL IN MAMMALIAN TISSUE | THE GREEN CROSS CORPORATION (JP) | 1996-08-06 | — | — | US | disclosed |
| EP-0633261-A1 | QUINOLINE-3-ACETIC ACID DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND USE THEREOF | THE GREEN CROSS CORPORATION (JP) | 1995-01-11 | — | — | EP | disclosed |