Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 9/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8303795 | 0.79 | AKR1B1 (0.48) | AKR1B1RXFP1AKR1A1MEN1KMT2A | |
| SCHEMBL8303442 | 0.78 | AKR1B1 (0.49) | AKR1B1RXFP1P2RX7MEN1KMT2A | |
| SCHEMBL8307388 | 0.75 | AKR1B1 (0.56) | AKR1B1AKR1A1 | |
| SCHEMBL8305325 | 0.75 | AKR1A1 (0.47) | AKR1B1AKR1A1 | |
| SCHEMBL8304794 | 0.74 | AKR1B1 (0.47) | AKR1B1RXFP1AKR1A1MEN1KMT2A | |
| SCHEMBL8303689 | 0.74 | KDM4E (0.40) | AKR1B1RXFP1MEN1KMT2AALDH1A1 | |
| SCHEMBL8307232 | 0.73 | AKR1B1 (0.60) | AKR1B1AKR1A1 | |
| SCHEMBL8304134 | 0.72 | AKR1B1 (0.54) | AKR1B1AKR1A1 | |
| SCHEMBL8307246 | 0.72 | AKR1B1 (0.54) | AKR1B1AKR1A1 | |
| SCHEMBL8304777 | 0.71 | AKR1B1 (0.45) | AKR1B1AKR1A1ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0633261-B1 | QUINOLINE-3-ACETIC ACID DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND USE THEREOF | YOSHITOMI PHARMACEUTICAL (JP) | 1999-04-21 | — | — | EP | disclosed |
| US-5543420-A | ALDOSE REDUCTASE INHIBITORS; ANTIDIABETIC AGENTS; PREVENTION OF ACCUMULATION OF SORBITOL AND GALACTITOL IN MAMMALIAN TISSUE | THE GREEN CROSS CORPORATION (JP) | 1996-08-06 | — | — | US | disclosed |
| EP-0633261-A1 | QUINOLINE-3-ACETIC ACID DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND USE THEREOF | THE GREEN CROSS CORPORATION (JP) | 1995-01-11 | — | — | EP | disclosed |