Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | FBP1 | P09467 | 8/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.37 |
| ▸ | FEN1 | P39748 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6789519 | 0.82 | CA2 (0.45) | KMT2AFEN1PTPN1CA2 | |
| SCHEMBL6754040 | 0.81 | ALDH1A1 (0.43) | GAAATMKMT2AMMP2MAOA | |
| SCHEMBL8304958 | 0.72 | GAA (0.36) | GAAATMKMT2AALDH1A1MAPT | |
| SCHEMBL6784875 | 0.72 | F2 (0.39) | MMP2MAPTCA2 | |
| SCHEMBL8303252 | 0.72 | MAPT (0.41) | KMT2AMMP2MAOAALDH1A1MAPT | |
| SCHEMBL6756435 | 0.72 | CA2 (0.46) | GAAMMP2ALDH1A1MAPTCA2 | |
| SCHEMBL27337035 | 0.68 | KMT2A (0.46) | ATMKMT2AMMP2FBP1ALDH1A1 | |
| SCHEMBL17410625 | 0.67 | KMT2A (0.49) | ATMKMT2AMMP2FBP1ALDH1A1 | |
| SCHEMBL24517491 | 0.67 | KMT2A (0.52) | KMT2AMMP2FBP1ALDH1A1MAPT | |
| SCHEMBL6832061 | 0.66 | ALDH1A1 (0.57) | KMT2AFBP1ALDH1A1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0749430-B1 | THIAZOLIDINEDIONE DERIVATIVES AS ANTI-HYPERGLYCEMIC AGENTS | AMERICAN HOME PROD (US) | 1999-08-25 | — | — | EP | disclosed |
| US-5605918-A | SUBSTITUTED THIAZOLIDINE-2,4-DIONES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-02-25 | — | — | US | disclosed |
| US-5574051-A | HYPOGLYCEMIC | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-11-12 | — | — | US | disclosed |
| WO-1995024400-A1 | THIAZOLIDINEDIONE DERIVATIVES AS ANTI-HYPERGLYCEMIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-09-14 | — | — | WO | disclosed |