Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 3/20 | 0.52 |
| ▸ | PPARA | Q07869 | 3/20 | 0.52 |
| ▸ | S1PR1 | P21453 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8304871 | 1.00 | PPARG (0.52) | PPARGPPARAS1PR1LMNASMN1; SMN2 | |
| SCHEMBL8304589 | 0.95 | PPARA (0.55) | PPARGPPARAS1PR1LMNASMN1; SMN2 | |
| SCHEMBL5609899 | 0.83 | LMNA (0.65) | PPARGPPARAS1PR1LMNASMN1; SMN2 | |
| SCHEMBL5609892 | 0.83 | LMNA (0.65) | PPARGPPARAS1PR1LMNASMN1; SMN2 | |
| SCHEMBL8443076 | 0.82 | LMNA (0.42) | PPARGPPARAS1PR1LMNASMN1; SMN2 | |
| SCHEMBL14418609 | 0.82 | SLC6A4 (0.60) | PPARGPPARAS1PR1LMNASMN1; SMN2 | |
| SCHEMBL5610797 | 0.81 | LMNA (0.56) | PPARGPPARAS1PR1LMNASMN1; SMN2 | |
| SCHEMBL8309933 | 0.81 | PPARA (0.48) | PPARGPPARAS1PR1LMNASMN1; SMN2 | |
| SCHEMBL8309932 | 0.81 | PPARA (0.48) | PPARGPPARAS1PR1LMNASMN1; SMN2 | |
| SCHEMBL5610798 | 0.81 | LMNA (0.56) | PPARGPPARAS1PR1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5972959-A | Oxime derivatives, their preparation and their therapeutic use | SANKYO COMPANY, LIMITED (JP) | 1999-10-26 | — | — | US | disclosed |
| EP-0708098-B1 | Oxime derivatives, their preparation and their therapeutic use | SANKYO CO (JP) | 1999-03-03 | — | — | EP | disclosed |
| EP-0708098-A1 | Oxime derivatives, their preparation and their therapeutic use | SANKYO COMPANY LIMITED (JP) | 1996-04-24 | — | — | EP | disclosed |