Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 14/20 | 0.56 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.49 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.42 |
| ▸ | CCR2 | P41597 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8308575 | 0.88 | PTGS2 (0.68) | PTGS2PTGS1HAO1 | |
| SCHEMBL8570396 | 0.86 | PTGS2 (0.60) | PTGS2PTGS1 | |
| SCHEMBL3000770 | 0.84 | HAO1 (0.56) | PTGS2PTGS1HAO1ALOX5 | |
| SCHEMBL8303948 | 0.84 | PTGS2 (0.59) | PTGS2PTGS1HAO1 | |
| SCHEMBL8310335 | 0.84 | PTGS2 (0.59) | PTGS2PTGS1 | |
| SCHEMBL8308253 | 0.82 | PTGS2 (0.60) | PTGS2PTGS1 | |
| SCHEMBL8444527 | 0.81 | PTGS2 (0.52) | PTGS2PTGS1 | |
| SCHEMBL8304224 | 0.81 | PTGS2 (0.52) | PTGS2PTGS1HAO1 | |
| SCHEMBL8440041 | 0.79 | PTGS2 (0.50) | PTGS2PTGS1 | |
| SCHEMBL8303577 | 0.79 | PTGS2 (0.51) | PTGS2PTGS1HAO1ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0915848-A1 | 1,2-DIARYLINDOLE AS COX-2 INHIBITORS | LABORATOIRES UPSA (FR) | 1999-05-19 | — | — | EP | disclosed |
| WO-1998005639-A1 | 1,2-DIARYLINDOLE AS COX-2 INHIBITORS | LABORATOIRES UPSA (FR) | 1998-02-12 | — | — | WO | disclosed |