Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27662899 | 0.91 | HSD17B10 (0.47) | GPR119KDM4EHSD17B10MAPTTHRB | |
| SCHEMBL10296221 | 0.88 | MAPT (0.46) | GPR119KDM4EMAPTTHRBHPGD | |
| SCHEMBL28974047 | 0.87 | GPR119 (0.49) | GPR119KDM4EMAPTTHRBHPGD | |
| SCHEMBL23979945 | 0.85 | ALDH1A1 (0.45) | GPR119KDM4EMAPTTHRBHPGD | |
| SCHEMBL4722920 | 0.85 | HPGD (0.47) | GPR119KDM4EHSD17B10MAPTTHRB | |
| SCHEMBL24812373 | 0.84 | NR1H2 (0.42) | GPR119KDM4EMAPTTHRBHPGD | |
| SCHEMBL1006353 | 0.84 | KDM4E (0.43) | GPR119KDM4EMAPTTHRBHPGD | |
| SCHEMBL3114371 | 0.84 | KDM4E (0.43) | GPR119KDM4EMAPTTHRBHPGD | |
| SCHEMBL3621172 | 0.83 | BRD4 (0.38) | HSD17B10EPHX1USP2SMN1; SMN2ALDH1A1 | |
| SCHEMBL652243 | 0.82 | MEN1 (0.45) | GPR119KDM4EHSD17B10MAPTTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101450947-B | 7-(3-oximido-4-amido-4-alkyl-1-piperidine)quinoline carboxylic acid derivates and preparation method thereof | INST MED BIOTECHNOLOGY CAMS | 2011-09-14 | — | — | CN | disclosed |
| CN-101450947-A | 7-(3-oximido-4-amido-4-alkyl-1-piperidine)quinoline carboxylic acid derivates and preparation method thereof | MEDICINE AND BIOENGINEERING IN (CN) | 2009-06-10 | — | — | CN | disclosed |
| EP-0897303-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-02-24 | — | — | EP | disclosed |
| EP-0897303-A4 | — | — | 1999-02-24 | — | — | EP | disclosed |
| WO-1997036605-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-10-09 | — | — | WO | disclosed |