Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | PLAT | P00750 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6631827 | 0.79 | MAPK1 (0.35) | KDM4EMAPTTHRBMAPK1 | |
| SCHEMBL6595132 | 0.77 | PARP1 (0.31) | MAPK1 | |
| SCHEMBL12426356 | 0.76 | CHRM3 (0.40) | KDM4EMAPK1 | |
| SCHEMBL1514914 | 0.74 | TSHR (0.41) | KDM4EMAPTTHRBPLAT | |
| SCHEMBL27753414 | 0.73 | — | — | |
| SCHEMBL2300592 | 0.72 | ALDH1A1 (0.46) | KDM4EMAPT | |
| SCHEMBL2146291 | 0.72 | TSHR (0.34) | KDM4EMAPTTHRBPLAT | |
| SCHEMBL6634675 | 0.71 | MAPK1 (0.38) | KDM4EMAPTTHRBMAPK1 | |
| Hydrochloric Acid SCHEMBL2302998 | 0.71 | MAPT (0.45) | KDM4EMAPT | |
| SCHEMBL10587651 | 0.71 | MAPK1 (0.33) | MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0897303-A4 | — | — | 1999-02-24 | — | — | EP | disclosed |
| EP-0897303-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-02-24 | — | — | EP | disclosed |
| WO-1997036605-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-10-09 | — | — | WO | disclosed |