Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | CASP3 | P42574 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | CCR2 | P41597 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6634675 | 0.80 | MAPK1 (0.38) | MAPK1GAAKDM4EMAPTTHRB | |
| SCHEMBL8304912 | 0.79 | KDM4E (0.32) | MAPK1KDM4EMAPTTHRB | |
| SCHEMBL3780480 | 0.78 | MAPK1 (0.41) | MAPK1KDM4ETHRB | |
| SCHEMBL16925438 | 0.78 | TLR4 (0.47) | GAAKDM4EMAPT | |
| SCHEMBL2720348 | 0.78 | L3MBTL1 (0.50) | L3MBTL1GAACCR2 | |
| SCHEMBL6283782 | 0.77 | MAPK1 (0.46) | MAPK1GAAKDM4E | |
| SCHEMBL27571076 | 0.73 | CCR2 (0.48) | L3MBTL1CCR2 | |
| SCHEMBL25700006 | 0.71 | SLC6A1 (0.55) | MAPK1KDM4EMAPT | |
| SCHEMBL160676 | 0.71 | SLC6A1 (0.55) | MAPK1KDM4EMAPT | |
| SCHEMBL12426356 | 0.71 | CHRM3 (0.40) | MAPK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1383748-A2 | NOVEL COMPOUNDS AND COMPOSITIONS AS CATHEPSIN INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2004-01-28 | — | — | EP | claimed |
| WO-2002051983-A2 | NOVEL COMPOUNDS AND COMPOSITIONS AS CATHEPSIN INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2002-07-04 | — | — | WO | claimed |