SCHEMBL8304917

SCHEMBL8304917

CCCc1c(O)cc2oc(-c3ccc(OC)c(O)c3)cc(=O)c2c1O

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A1 P04798 4/20 0.67
CYP1B1 Q16678 4/20 0.67
AURKA O14965 1/20 0.67
KDR P35968 1/20 0.67
FLT3 P36888 1/20 0.67
AURKB Q96GD4 1/20 0.67
HDAC6 Q9UBN7 2/20 0.64
CYP1A2 P05177 2/20 0.64
KDM1A O60341 1/20 0.64
ABCC1 P33527 1/20 0.64
XDH P47989 1/20 0.64
IPMK Q8NFU5 1/20 0.64
IP6K2 Q9UHH9 1/20 0.64
HSD17B2 P37059 1/20 0.58
TAS2R31 P59538 1/20 0.58
KDM4E B2RXH2 1/20 0.57
MEN1 O00255 1/20 0.57
NPC1 O15118 1/20 0.57
POLB P06746 1/20 0.57
AMY1A P0DUB6 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10001087 0.89 CYP1B1 (0.70) CYP1A1CYP1B1AURKAKDRFLT3
SCHEMBL8570704 0.86 HDAC6 (0.58) CYP1A1CYP1B1AURKAKDRFLT3
SCHEMBL8308179 0.86 HDAC6 (0.51) CYP1A1CYP1B1AURKAKDRFLT3
SCHEMBL8305265 0.85 CYP1B1 (0.65) CYP1A1CYP1B1AURKAKDRFLT3
SCHEMBL8570785 0.84 HDAC6 (0.56) CYP1A1CYP1B1AURKAKDRFLT3
SCHEMBL8052891 0.84 HDAC6 (0.69) CYP1A1CYP1B1AURKAKDRFLT3
SCHEMBL8307616 0.83 CYP1A1 (0.58) CYP1A1CYP1B1AURKAKDRFLT3
SCHEMBL30799172 0.83 FLT3 (0.86) CYP1A1CYP1B1AURKAKDRFLT3
SCHEMBL8069022 0.83 FLT3 (0.86) CYP1A1CYP1B1AURKAKDRFLT3
SCHEMBL30787094 0.83 CYP1B1 (0.82) CYP1A1CYP1B1AURKAKDRFLT3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0709383-B1 Diosmetin derivatives, process for their preparation and pharmaceutical compositions containing them ADIR (FR) 1999-12-15 EP disclosed
US-5629339-A CHRONIC VENOUS INSUFFICIENCY ADIR ET COMPAGNIE (FR) 1997-05-13 US disclosed
EP-0709383-A1 Diosmetin derivatives, process for their preparation and pharmaceutical compositions containing them ADIR ET COMPAGNIE (FR) 1996-05-01 EP disclosed