Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA2 | P42262 | 16/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8307491 | 0.81 | GRIA2 (0.45) | GRIA2CYP1A2PSEN1PSEN2APH1B | |
| SCHEMBL8303647 | 0.79 | HDAC8 (0.45) | GRIA2NR1H2 | |
| SCHEMBL8304894 | 0.79 | HDAC8 (0.40) | GRIA2CYP1A2NR1H2PSEN1PSEN2 | |
| SCHEMBL8715200 | 0.78 | PDE4A (0.48) | GRIA2NR1H2HRH3PSEN1PSEN2 | |
| SCHEMBL9414691 | 0.77 | HDAC8 (0.38) | GRIA2NR1H2PSEN1PSEN2APH1B | |
| Hydrochloric Acid SCHEMBL8718128 | 0.77 | HDAC8 (0.37) | GRIA2NR1H2PSEN1PSEN2APH1B | |
| SCHEMBL8308496 | 0.76 | ALDH1A1 (0.52) | GRIA2NR1H2 | |
| SCHEMBL8305943 | 0.76 | HDAC8 (0.37) | GRIA2CYP1A2PSEN1PSEN2APH1B | |
| SCHEMBL8304185 | 0.75 | HDAC8 (0.37) | GRIA2CYP1A2NR1H2PSEN1PSEN2 | |
| SCHEMBL8302585 | 0.74 | MAPT (0.46) | GRIA2CYP1A2PSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0579059-B1 | Pyridazinone derivatives and processes for preparing the same | TANABE SEIYAKU CO (JP) | 1999-05-12 | — | — | EP | disclosed |
| US-5739132-A | ENDOTHOXIN SHOCK; NEPHRITIS | TANABE SEIYAKU CO., LTD. (JP) | 1998-04-14 | — | — | US | disclosed |
| EP-0579059-A1 | Pyridazinone derivatives and processes for preparing the same | TANABE SEIYAKU CO., LTD. (JP) | 1994-01-19 | — | — | EP | disclosed |