Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | GRIA2 | P42262 | 15/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8303647 | 0.86 | HDAC8 (0.45) | HDAC8GRIA2NR1H2 | |
| SCHEMBL8715200 | 0.85 | PDE4A (0.48) | HDAC8GRIA2PSEN1PSEN2APH1B | |
| SCHEMBL8308496 | 0.82 | ALDH1A1 (0.52) | HDAC8GRIA2NR1H2 | |
| SCHEMBL9414691 | 0.82 | HDAC8 (0.38) | HDAC8GRIA2PSEN1PSEN2APH1B | |
| SCHEMBL8304185 | 0.81 | HDAC8 (0.37) | HDAC8GRIA2PSEN1PSEN2APH1B | |
| Hydrochloric Acid SCHEMBL8718128 | 0.81 | HDAC8 (0.37) | HDAC8GRIA2PSEN1PSEN2APH1B | |
| SCHEMBL8305943 | 0.81 | HDAC8 (0.37) | HDAC8GRIA2PSEN1PSEN2APH1B | |
| SCHEMBL8304993 | 0.79 | GRIA2 (0.43) | GRIA2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL9414967 | 0.78 | HDAC8 (0.45) | HDAC8GRIA2PSEN1PSEN2APH1B | |
| Hydrochloric Acid SCHEMBL8719903 | 0.78 | HDAC8 (0.45) | HDAC8GRIA2PSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0579059-B1 | Pyridazinone derivatives and processes for preparing the same | TANABE SEIYAKU CO (JP) | 1999-05-12 | — | — | EP | disclosed |
| US-5739132-A | ENDOTHOXIN SHOCK; NEPHRITIS | TANABE SEIYAKU CO., LTD. (JP) | 1998-04-14 | — | — | US | disclosed |
| EP-0579059-A1 | Pyridazinone derivatives and processes for preparing the same | TANABE SEIYAKU CO., LTD. (JP) | 1994-01-19 | — | — | EP | disclosed |