Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K7 | O43318 | 1/20 | 0.52 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | BRD4 | O60885 | 4/20 | 0.45 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.44 |
| ▸ | PTGER2 | P43116 | 3/20 | 0.44 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.44 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
| ▸ | MMP1 | P03956 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | MMP2 | P08253 | 2/20 | 0.41 |
| ▸ | MMP3 | P08254 | 2/20 | 0.41 |
| ▸ | MMP9 | P14780 | 2/20 | 0.41 |
| ▸ | MMP12 | P39900 | 2/20 | 0.41 |
| ▸ | MMP13 | P45452 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8305578 | 1.00 | MAP3K7 (0.52) | MAP3K7TAB1HDAC8BRD4PTGER4 | |
| SCHEMBL16589531 | 0.84 | MAP3K7 (0.57) | MAP3K7TAB1HDAC8BRD4PTGER4 | |
| SCHEMBL8304176 | 0.80 | L3MBTL1 (0.48) | BRD4MAPTBTK | |
| SCHEMBL19651747 | 0.78 | PTGER4 (0.70) | MAP3K7TAB1HDAC8BRD4PTGER4 | |
| SCHEMBL7770104 | 0.78 | PTGER4 (0.70) | MAP3K7TAB1HDAC8BRD4PTGER4 | |
| SCHEMBL8307738 | 0.78 | BRD4 (0.48) | HDAC8BRD4MAPTBTKALDH1A1 | |
| SCHEMBL9749330 | 0.77 | MAPT (0.55) | BRD4MAPTALDH1A1HPGDHTT | |
| SCHEMBL9749338 | 0.77 | MAPT (0.55) | BRD4MAPTALDH1A1HPGDHTT | |
| SCHEMBL5093979 | 0.77 | HDAC8 (0.52) | MAP3K7TAB1HDAC8PTGER4PTGER2 | |
| SCHEMBL5093974 | 0.77 | HDAC8 (0.52) | MAP3K7TAB1HDAC8PTGER4PTGER2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0469833-B1 | N-Benzyl-Indoles, processes for their preparation and pharmaceutical compositions containing them | LILLY CO ELI (GB) | 1999-09-08 | — | — | EP | disclosed |
| US-5281593-A | Pharmaceuticals | LILLY INDUSTRIES LIMITED (GB) | 1994-01-25 | — | — | US | disclosed |
| EP-0469833-A1 | N-Benzyl-Indoles, processes for their preparation and pharmaceutical compositions containing them | LILLY INDUSTRIES LIMITED (GB) | 1992-02-05 | — | — | EP | disclosed |