Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | NPC1 | O15118 | 4/20 | 0.55 |
| ▸ | RAB9A | P51151 | 4/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.50 |
| ▸ | CCR6 | P51684 | 1/20 | 0.50 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.50 |
| ▸ | TLR4 | O00206 | 5/20 | 0.46 |
| ▸ | TLR2 | O60603 | 5/20 | 0.46 |
| ▸ | MAOA | P21397 | 5/20 | 0.46 |
| ▸ | MAOB | P27338 | 5/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9749330 | 1.00 | MAPT (0.55) | MAPTNPSR1LMNASMN1; SMN2NPC1 | |
| SCHEMBL8304176 | 0.81 | L3MBTL1 (0.48) | MAPTSMN1; SMN2NPC1RAB9AMAOA | |
| SCHEMBL30130381 | 0.78 | MAPT (0.58) | MAPTNPSR1LMNASMN1; SMN2NPC1 | |
| SCHEMBL19693006 | 0.78 | MAPT (0.58) | MAPTNPSR1LMNASMN1; SMN2NPC1 | |
| SCHEMBL30130382 | 0.78 | MAPT (0.58) | MAPTNPSR1LMNASMN1; SMN2NPC1 | |
| SCHEMBL8305578 | 0.77 | MAP3K7 (0.52) | MAPTHPGDHTTALDH1A1KDM4E | |
| SCHEMBL8305581 | 0.77 | MAP3K7 (0.52) | MAPTHPGDHTTALDH1A1KDM4E | |
| SCHEMBL27947570 | 0.77 | CCNB2 (0.63) | MAPTNPSR1LMNASMN1; SMN2NPC1 | |
| SCHEMBL9749866 | 0.75 | LTA4H (0.46) | MAPTNPSR1LMNASMN1; SMN2NPC1 | |
| SCHEMBL10679463 | 0.74 | BTK (0.42) | MAPTNPSR1LMNASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0266349-B1 | TRICYCLIC INDOLE DERIVATIVES, THEIR MANUFACTURE AND USE AS MEDICINES | SCHERING AKTIENGESELLSCHAFT (DE) | 1992-03-18 | — | — | EP | disclosed |
| EP-0266349-A1 | TRICYCLIC INDOLE DERIVATIVES, THEIR MANUFACTURE AND USE AS MEDICINES. | SCHERING AG (DE) | 1988-05-11 | — | — | EP | disclosed |
| WO-1987000522-A1 | TRICYCLIC INDOLE DERIVATIVES, THEIR MANUFACTURE AND USE AS MEDICINES | SCHERING AKTIENGESELLSCHAFT BERLIN UND BERGKAMEN (DE) | 1987-01-29 | — | — | WO | disclosed |