Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | SMPD2 | O60906 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ANPEP | P15144 | 1/20 | 0.39 |
| ▸ | MME | P08473 | 1/20 | 0.39 |
| ▸ | ACE | P12821 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8305851 | 1.00 | KMT2A (0.46) | KMT2AALDH1A1TDP1KDM4ESMPD2 | |
| SCHEMBL7748918 | 0.89 | ALDH1A1 (0.45) | KMT2AALDH1A1TDP1KDM4EMEN1 | |
| SCHEMBL7748913 | 0.89 | ALDH1A1 (0.45) | KMT2AALDH1A1TDP1KDM4EMEN1 | |
| SCHEMBL7393110 | 0.76 | KMT2A (0.50) | KMT2AALDH1A1TDP1MEN1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL4236114 | 0.75 | KMT2A (0.48) | KMT2AALDH1A1TDP1KDM4EMEN1 | |
| Hydrochloric Acid SCHEMBL4226418 | 0.75 | KMT2A (0.49) | KMT2AALDH1A1TDP1KDM4EMEN1 | |
| SCHEMBL181325 | 0.73 | TDP1 (0.61) | KMT2AALDH1A1TDP1KDM4EMEN1 | |
| SCHEMBL7748818 | 0.70 | KMT2A (0.44) | KMT2AALDH1A1TDP1KDM4EMEN1 | |
| SCHEMBL7748820 | 0.70 | KMT2A (0.44) | KMT2AALDH1A1TDP1KDM4EMEN1 | |
| SCHEMBL4679636 | 0.69 | ATM (0.55) | KMT2AALDH1A1TDP1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0952842-A2 | A METHOD OF TREATING CANCER | Merck & Co., Inc. (US) | 1999-11-03 | — | — | EP | disclosed |
| WO-1997038664-A2 | A METHOD OF TREATING CANCER | MERCK & CO., INC. (US) | 1997-10-23 | — | — | WO | disclosed |