SCHEMBL8306162

SCHEMBL8306162

O=C(O)c1cc(F)cc(OCc2ccccc2)c1

nearest known ligand 0.79

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.79
KMT2A Q03164 1/20 0.79
NR4A2 P43354 8/20 0.65
NR4A1 P22736 1/20 0.61
NR4A3 Q92570 1/20 0.61
PTGER1 P34995 1/20 0.60
SRD5A2 P31213 2/20 0.57
PPARA Q07869 1/20 0.55
PLA2G4B P0C869 1/20 0.54
MAOB P27338 1/20 0.54
GCK P35557 1/20 0.52
MRGPRX4 Q96LA9 2/20 0.51
TSHR P16473 1/20 0.51
SMN1; SMN2 Q16637 1/20 0.51
SMPD1 P17405 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL862870 0.89 MEN1 (0.93) MEN1KMT2ANR4A2NR4A1NR4A3
SCHEMBL1426961 0.89 MEN1 (1.00) MEN1KMT2ANR4A2NR4A1NR4A3
SCHEMBL16115550 0.88 KMT2A (0.60) MEN1KMT2ANR4A2NR4A1NR4A3
Hydrochloric Acid SCHEMBL6841086 0.87 MEN1 (0.96) MEN1KMT2ANR4A2NR4A1NR4A3
SCHEMBL16137686 0.87 KMT2A (0.59) MEN1KMT2ANR4A2NR4A1NR4A3
SCHEMBL20955228 0.85 RAB9A (0.67) MEN1KMT2ANR4A2PPARAPLA2G4B
SCHEMBL7809050 0.85 KMT2A (0.57) MEN1KMT2ANR4A2NR4A1NR4A3
SCHEMBL2659482 0.84 KMT2A (0.73) MEN1KMT2ANR4A2NR4A1NR4A3
SCHEMBL2570286 0.84 MEN1 (0.84) MEN1KMT2ANR4A2NR4A1NR4A3
SCHEMBL5042093 0.83 ALOX5 (0.55) MEN1KMT2AMAOBSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2978754-B1 BIARYL-PROPIONIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS SANOFI SA (FR) 2017-05-10 EP disclosed
EP-2978754-B1 BIARYL-PROPIONIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS SANOFI SA (FR) 2017-05-10 EP disclosed
EP-2978747-B1 BIARYL-PROPIONIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS SANOFI SA (FR) 2017-04-19 EP disclosed
EP-2978747-B1 BIARYL-PROPIONIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS SANOFI SA (FR) 2017-04-19 EP disclosed
EP-2978747-A1 BIARYL-PROPIONIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS SANOFI (FR) 2016-02-03 EP disclosed
EP-2978754-A1 BIARYL-PROPIONIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS SANOFI (FR) 2016-02-03 EP disclosed
WO-2014154727-A1 BIARYL-PROPIONIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS SANOFI (FR) 2014-10-02 WO disclosed
WO-2014154726-A1 BIARYL-PROPIONIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS SANOFI (FR) 2014-10-02 WO disclosed
WO-2014154727-A1 BIARYL-PROPIONIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS SANOFI (FR) 2014-10-02 WO disclosed
WO-2014154726-A1 BIARYL-PROPIONIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS SANOFI (FR) 2014-10-02 WO disclosed
CN-1087291-C N-hydroxyureas as anti-inflammatory agents PFIZER (US) 2002-07-10 CN disclosed
EP-0832078-B1 N-HYDROXYUREAS AS ANTIINFLAMMATORY AGENTS PFIZER (US) 1999-10-20 EP disclosed
US-5814648-A N-hydroxyureas as antiinflammatory agents PFIZER INC. (US) 1998-09-29 US disclosed
CN-1191531-A N-hydroxyureas as antiinflammatory agents PFIZER (US) 1998-08-26 CN disclosed
EP-0832078-A1 N-HYDROXYUREAS AS ANTIINFLAMMATORY AGENTS PFIZER INC. (US) 1998-04-01 EP disclosed
WO-1996040659-A1 N-HYDROXYUREAS AS ANTIINFLAMMATORY AGENTS PFIZER INC. (US) 1996-12-19 WO disclosed