Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9530316 | 0.95 | ALDH1A1 (0.36) | ALDH1A1GAAHSD17B10MAPTKDM4E | |
| SCHEMBL8305148 | 0.90 | ALDH1A1 (0.38) | ALDH1A1GAAHSD17B10MAPTKDM4E | |
| SCHEMBL8301972 | 0.83 | ALDH1A1 (0.33) | ALDH1A1GAAHSD17B10MAPTKDM4E | |
| SCHEMBL8308098 | 0.81 | ALDH1A1 (0.43) | ALDH1A1GAAHSD17B10MAPTKDM4E | |
| SCHEMBL8304048 | 0.79 | ALDH1A1 (0.37) | ALDH1A1GAAHSD17B10MAPTKDM4E | |
| SCHEMBL8307056 | 0.79 | ALDH1A1 (0.43) | ALDH1A1GAAHSD17B10MAPTKDM4E | |
| SCHEMBL8301746 | 0.79 | ALDH1A1 (0.33) | ALDH1A1GAAHSD17B10MAPTKDM4E | |
| SCHEMBL12333770 | 0.77 | ALDH1A1 (0.49) | ALDH1A1GAAHSD17B10MAPTKDM4E | |
| SCHEMBL8304593 | 0.77 | PARP1 (0.40) | GAAMAPT | |
| SCHEMBL8303929 | 0.76 | ALDH1A1 (0.37) | ALDH1A1GAAHSD17B10MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0548254-B1 | 6- OR 7-(IMIDAZOLIDIN-2-YLIDENEAMINO)-1,4-BENZOXAZINES AS ALPHA ADRENERGIC AGENTS | ALLERGAN INC (US) | 1999-06-02 | — | — | EP | disclosed |
| US-5091528-A | Antiglaucoma, antidiarrhea agents, diuretics, vasoconstrictors | ALLERGAN, INC. (US) | 1992-02-25 | — | — | US | disclosed |