SCHEMBL830644

SCHEMBL830644

C=C(C)C(=O)OCn1c(=O)[nH]c(=O)n(COC(=O)C(=C)C)c1=O

nearest known ligand 0.43

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.43
APEX1 P27695 2/20 0.41
ALDH1A1 P00352 2/20 0.39
THRB P10828 1/20 0.37
CYP2C9 P11712 2/20 0.34
KMT2A Q03164 2/20 0.34
MAPT P10636 1/20 0.34
HTT P42858 2/20 0.32
CYP1A2 P05177 3/20 0.31
CYP2C19 P33261 3/20 0.31
TDP1 Q9NUW8 2/20 0.31
GAA P10253 2/20 0.31
POLB P06746 2/20 0.31
MEN1 O00255 1/20 0.31
NPC1 O15118 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL831448 0.89 TSHR (0.47) TSHRAPEX1ALDH1A1THRBKMT2A
SCHEMBL28004954 0.86 TSHR (0.43) TSHRAPEX1ALDH1A1THRBHTT
SCHEMBL1280003 0.83 APEX1 (0.46) TSHRAPEX1ALDH1A1THRBCYP2C9
SCHEMBL9421608 0.81 TSHR (0.46) TSHRAPEX1ALDH1A1THRBCYP2C9
SCHEMBL486580 0.79 APEX1 (0.41) TSHRAPEX1ALDH1A1THRBKMT2A
SCHEMBL18927855 0.78 POLB (0.40) TSHRAPEX1ALDH1A1THRBHTT
SCHEMBL21657539 0.78 THRB (0.40) TSHRAPEX1ALDH1A1THRBHTT
SCHEMBL15633780 0.75 APEX1 (0.38) TSHRAPEX1ALDH1A1THRBMAPT
SCHEMBL831001 0.73 THRB (0.42) TSHRAPEX1ALDH1A1THRBKMT2A
SCHEMBL150780 0.73 THRB (0.48) TSHRAPEX1ALDH1A1THRBKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8142978-B2 Planographic printing plate precursor and printing method using the same FUJIFILM CORPORATION (JP) 2012-03-27 US disclosed
EP-1992482-B1 Planographic printing plate precursor and printing method using the same FUJIFILM CORP (JP) 2011-07-20 EP disclosed
EP-2165830-B1 Lithographic printing plate precursor and printing method using the same FUJIFILM CORP (JP) 2011-03-16 EP disclosed
US-20100071574-A1 LITHOGRAPHIC PRINTING PLATE PRECURSOR AND PRINTING METHOD USING THE SAME FUJIFILM CORPORATION (JP) 2010-03-25 US disclosed
EP-2165830-A1 Lithographic printing plate precursor and printing method using the same Fujifilm Corporation (JP) 2010-03-24 EP disclosed
US-20080286685-A1 PLANOGRAPHIC PRINTING PLATE PRECURSOR AND PRINTING METHOD USING THE SAME FUJIFILM CORPORATION (JP) 2008-11-20 US disclosed
EP-1992482-A2 Planographic printing plate precursor and printing method using the same FUJIFILM Corporation (JP) 2008-11-19 EP disclosed
EP-1577090-B1 Lithographic printing plate precursor FUJIFILM CORP (JP) 2007-06-06 EP disclosed
US-20050208423-A1 Lithographic printing plate precursor FUJI PHOTO FILM CO., LTD. 2005-09-22 US disclosed
EP-1577090-A2 Lithographic printing plate precursor FUJI PHOTO FILM CO., LTD. (JP) 2005-09-21 EP disclosed