⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL494491 | 0.74 | — | — | |
| SCHEMBL1069898 | 0.70 | — | — | |
| SCHEMBL31393398 | 0.68 | — | — | |
| SCHEMBL26638 | 0.55 | SIGMAR1 (0.33) | — | |
| SCHEMBL4376036 | 0.55 | — | — | |
| SCHEMBL5595562 | 0.55 | SIGMAR1 (0.33) | — | |
| SCHEMBL9093836 | 0.54 | — | — | |
| SCHEMBL9843327 | 0.53 | — | — | |
| SCHEMBL10486984 | 0.48 | KDM4E (0.31) | — | |
| SCHEMBL11736081 | 0.48 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0758312-B1 | SUBSTITUTED FUSED AND BRIDGED BICYCLIC COMPOUNDS AS THERAPEUTIC AGENTS | LILLY CO ELI (US) | 1999-12-22 | — | — | EP | claimed |
| EP-0758312-A4 | SUBSTITUTED FUSED AND BRIDGED BICYCLIC COMPOUNDS AS THERAPEUTIC AGENTS | LILLY CO ELI (US) | 1997-09-10 | — | — | EP | claimed |
| EP-0758312-A1 | SUBSTITUTED FUSED AND BRIDGED BICYCLIC COMPOUNDS AS THERAPEUTIC AGENTS | ELI LILLY AND COMPANY (US) | 1997-02-19 | — | — | EP | claimed |
| WO-1995030640-A1 | SUBSTITUTED FUSED AND BRIDGED BICYCLIC COMPOUNDS AS THERAPEUTIC AGENTS | ELI LILLY AND COMPANY (US) | 1995-11-16 | — | — | WO | claimed |
| EP-0758312-B1 | SUBSTITUTED FUSED AND BRIDGED BICYCLIC COMPOUNDS AS THERAPEUTIC AGENTS | LILLY CO ELI (US) | 1999-12-22 | — | — | EP | disclosed |
| US-5583221-A | ANTIINFLAMMATORY AGENTS, CARDIOVASCULAR DISORDERS, VIRICIDES, FUNGICIDES | ELI LILLY AND COMPANY (US) | 1996-12-10 | — | — | US | disclosed |
| WO-1995030640-A1 | SUBSTITUTED FUSED AND BRIDGED BICYCLIC COMPOUNDS AS THERAPEUTIC AGENTS | ELI LILLY AND COMPANY (US) | 1995-11-16 | — | — | WO | disclosed |