Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.43 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.40 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.39 |
| ▸ | BMP1 | P13497 | 1/20 | 0.39 |
| ▸ | CCR2 | P41597 | 3/20 | 0.38 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | SLC13A5 | Q86YT5 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8566646 | 1.00 | EPHX2 (0.43) | EPHX2NR1H4ENPP2TMEM97PTGS2 | |
| SCHEMBL8563783 | 0.83 | EPHX2 (0.46) | EPHX2NR1H4ENPP2PTGS2CCR2 | |
| SCHEMBL9969388 | 0.79 | TMEM97 (0.44) | EPHX2NR1H4ENPP2TMEM97PTGS2 | |
| SCHEMBL14467351 | 0.78 | POLB (0.42) | SLC13A5 | |
| SCHEMBL11293428 | 0.78 | MEN1 (0.47) | SLC13A5 | |
| SCHEMBL8081795 | 0.75 | EPHX2 (0.42) | EPHX2NR1H4CA1CA2SLC13A5 | |
| SCHEMBL6604251 | 0.72 | EPHX2 (0.39) | EPHX2NR1H4ENPP2PTGS2CA2 | |
| SCHEMBL8133933 | 0.72 | ENPP2 (0.48) | EPHX2NR1H4ENPP2PTGS2CA2 | |
| SCHEMBL8307666 | 0.72 | ENPP2 (0.43) | ENPP2PTGS2BMP1KCNJ1KCNH2 | |
| SCHEMBL8562357 | 0.71 | EPHX2 (0.43) | EPHX2NR1H4ENPP2PTGS2CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0904269-A1 | 3,4-DIARYL-2-HYDROXY-2,5-DIHYDROFURANS AS PRODRUGS TO COX-2 INHIBITORS | MERCK FROSST CANADA INC. (CA) | 1999-03-31 | — | — | EP | disclosed |
| EP-0863891-A1 | (METHYLSULFONYL)PHENYL-2-(5H)-FURANONES AS COX-2 INHIBITORS | MERCK FROSST CANADA INC. (CA) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997016435-A1 | 3,4-DIARYL-2-HYDROXY-2,5-DIHYDROFURANS AS PRODRUGS TO COX-2 INHIBITORS | MERCK FROSST CANADA INC. (CA) | 1997-05-09 | — | — | WO | disclosed |
| WO-1997014691-A1 | (METHYLSULFONYL)PHENYL-2-(5H)-FURANONES AS COX-2 INHIBITORS | MERCK FROSST CANADA INC. (CA) | 1997-04-24 | — | — | WO | disclosed |