Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.46 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | CCR2 | P41597 | 3/20 | 0.37 |
| ▸ | THRA | P10827 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8566646 | 0.83 | EPHX2 (0.43) | EPHX2NR1H4ENPP2PTGS2CCR2 | |
| SCHEMBL8306535 | 0.83 | EPHX2 (0.43) | EPHX2NR1H4ENPP2PTGS2CCR2 | |
| SCHEMBL8133933 | 0.82 | ENPP2 (0.48) | EPHX2NR1H4ENPP2PTGS2MEN1 | |
| SCHEMBL8562357 | 0.81 | EPHX2 (0.43) | EPHX2NR1H4ENPP2PTGS2AKR1C3 | |
| SCHEMBL20269465 | 0.81 | EPHX2 (0.43) | EPHX2NR1H4ENPP2PTGS2AKR1C3 | |
| SCHEMBL6460135 | 0.80 | HPGD (0.41) | MEN1ALDH1A1KMT2ATHRATHRB | |
| SCHEMBL5504958 | 0.78 | ESR1 (0.57) | MEN1KMT2A | |
| SCHEMBL3634160 | 0.78 | TSHR (0.50) | EPHX2NR1H4CA1CA2 | |
| SCHEMBL2600037 | 0.77 | ESR1 (0.50) | EPHX2NR1H4ENPP2PTGS2PTPN1 | |
| SCHEMBL8081741 | 0.77 | ENPP2 (0.44) | EPHX2NR1H4ENPP2PTGS2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111201212-B | Synthesis method of feloxicib and intermediate thereof | 四川青木制药有限公司 | 2022-07-26 | — | — | CN | disclosed |
| CN-107686471-B | Synthesis method of feloxicib and intermediate thereof | 成都苑东生物制药股份有限公司 | 2020-07-03 | — | — | CN | disclosed |
| CN-111201212-A | Synthesis method of feloxicib and intermediate thereof | 四川青木制药有限公司 | 2020-05-26 | — | — | CN | disclosed |
| EP-0863891-A1 | (METHYLSULFONYL)PHENYL-2-(5H)-FURANONES AS COX-2 INHIBITORS | MERCK FROSST CANADA INC. (CA) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997014691-A1 | (METHYLSULFONYL)PHENYL-2-(5H)-FURANONES AS COX-2 INHIBITORS | MERCK FROSST CANADA INC. (CA) | 1997-04-24 | — | — | WO | disclosed |