Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 6/20 | 0.42 |
| ▸ | MET | P08581 | 10/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8306603 | 1.00 | HIF1A (0.42) | HIF1AMETNPC1LMNARAB9A | |
| SCHEMBL5610798 | 0.79 | LMNA (0.56) | NPC1LMNARAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL5610797 | 0.79 | LMNA (0.56) | NPC1LMNARAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL8685877 | 0.76 | HIF1A (0.40) | HIF1ASMN1; SMN2EGLN1 | |
| SCHEMBL8310421 | 0.76 | KDM4E (0.55) | HIF1ANPC1RAB9ASMN1; SMN2EGLN1 | |
| SCHEMBL8310012 | 0.75 | KDM4C (0.43) | NPC1RAB9AL3MBTL1 | |
| SCHEMBL8310072 | 0.75 | PPARG (0.46) | METLMNAL3MBTL1 | |
| SCHEMBL8310069 | 0.75 | PPARG (0.46) | METLMNAL3MBTL1 | |
| SCHEMBL8304541 | 0.74 | PPARG (0.54) | METNPC1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL8442117 | 0.74 | MKNK1 (0.48) | LMNASMN1; SMN2L3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5972959-A | Oxime derivatives, their preparation and their therapeutic use | SANKYO COMPANY, LIMITED (JP) | 1999-10-26 | — | — | US | disclosed |
| EP-0708098-B1 | Oxime derivatives, their preparation and their therapeutic use | SANKYO CO (JP) | 1999-03-03 | — | — | EP | disclosed |
| EP-0708098-A1 | Oxime derivatives, their preparation and their therapeutic use | SANKYO COMPANY LIMITED (JP) | 1996-04-24 | — | — | EP | disclosed |