Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 6/20 | 0.40 |
| ▸ | CTSA | P10619 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ACACB | O00763 | 1/20 | 0.33 |
| ▸ | ACACA | Q13085 | 1/20 | 0.33 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6937012 | 0.79 | SMN1; SMN2 (0.46) | SMN1; SMN2 | |
| SCHEMBL8310421 | 0.77 | KDM4E (0.55) | HIF1ACTSAMEN1KMT2ATDP1 | |
| SCHEMBL8306601 | 0.76 | HIF1A (0.42) | HIF1ASMN1; SMN2EGLN1 | |
| SCHEMBL8306603 | 0.76 | HIF1A (0.42) | HIF1ASMN1; SMN2EGLN1 | |
| SCHEMBL8685836 | 0.74 | MKNK1 (0.43) | CTSA | |
| SCHEMBL8686143 | 0.73 | LDHA (0.49) | SMN1; SMN2 | |
| SCHEMBL8686093 | 0.72 | PPARG (0.47) | TDP1 | |
| SCHEMBL8686106 | 0.71 | PDE3B (0.36) | SMN1; SMN2 | |
| SCHEMBL8686194 | 0.71 | KMT2A (0.44) | MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL6264166 | 0.70 | MAPT (0.53) | HIF1ACTSAMEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5780490-A | A O-(2,4-OXA(OR THIA)ZOLIDINYL)PHENYLOXY(OR THIO OR AMINO) ALKYLOXIME; ALDOSE REDUCTASE INHIBITORS; ANTIDIABETIC AND -HYPOGLYCEMIC AGENTS; LIVER, SKIN AND UROGENITAL DISORDERS | SANKYO COMPANY, LIMITED (JP) | 1998-07-14 | — | — | US | disclosed |
| US-5703096-A | ANTIDIABETIC AGENTS; ALDOSE REDUCTASE INHIBITOR | SANKYO COMPANY, LIMITED (JP) | 1997-12-30 | — | — | US | disclosed |