Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 1/20 | 0.54 |
| ▸ | HTR2A | P28223 | 1/20 | 0.54 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9760169 | 0.88 | HTR2A (0.52) | DRD4HTR2APARP1 | |
| SCHEMBL8302548 | 0.88 | DRD4 (0.67) | DRD4HTR2A | |
| SCHEMBL8301640 | 0.87 | DRD4 (0.66) | DRD4HTR2A | |
| SCHEMBL7990238 | 0.85 | LMNA (0.58) | — | |
| Hydrochloric Acid SCHEMBL7993287 | 0.84 | LMNA (0.57) | — | |
| SCHEMBL8302387 | 0.80 | PARP1 (0.47) | PARP1 | |
| SCHEMBL8301654 | 0.79 | PARP1 (0.46) | PARP1 | |
| SCHEMBL7993315 | 0.76 | DRD4 (0.56) | DRD4HTR2A | |
| SCHEMBL8307680 | 0.75 | HTR2A (0.65) | DRD4HTR2A | |
| Hydrochloric Acid SCHEMBL7979047 | 0.75 | DRD4 (0.55) | DRD4HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0458234-B1 | 3-[1,Thiazolidinylbutyl-4-piperazinyl]-1H-indazoles, a process for their preparation and their use as medicaments | HOECHST MARION ROUSSEL INC (US) | 1999-03-31 | — | — | EP | disclosed |
| EP-0458234-A2 | 3-[1,Thiazolidinylbutyl-4-piperazinyl]-1H-indazoles, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-11-27 | — | — | EP | disclosed |
| US-5041445-A | Antipsychotic agents | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-08-20 | — | — | US | disclosed |