Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 17/20 | 0.67 |
| ▸ | PRKDC | P78527 | 6/20 | 0.67 |
| ▸ | ATM | Q13315 | 3/20 | 0.67 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.65 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.55 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5684569 | 0.91 | ATR (0.63) | ATRPRKDCATMAKR1B1CDK5 | |
| SCHEMBL11908281 | 0.87 | ATR (0.67) | ATRPRKDCATMAKR1B1 | |
| SCHEMBL8307717 | 0.84 | ATR (0.69) | ATRPRKDCATMCDK5CDK5R1 | |
| SCHEMBL318797 | 0.81 | ATR (0.68) | ATRPRKDCATM | |
| SCHEMBL557954 | 0.80 | ATR (0.72) | ATRPRKDCATM | |
| SCHEMBL18177423 | 0.80 | ATR (1.00) | ATRPRKDCATM | |
| SCHEMBL3462610 | 0.77 | ATR (0.63) | ATRPRKDCATM | |
| SCHEMBL3408307 | 0.76 | ATR (0.61) | ATRPRKDCATMCDK5CDK5R1 | |
| SCHEMBL24248259 | 0.76 | ATR (0.67) | ATRPRKDCATM | |
| SCHEMBL3461099 | 0.76 | ATR (0.68) | ATRPRKDCATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0914318-A1 | PYRAZINES | KINGS COLLEGE LONDON (GB) | 1999-05-12 | — | — | EP | disclosed |
| WO-1997043267-A1 | PYRAZINES | KINGS COLLEGE LONDON (GB) | 1997-11-20 | — | — | WO | disclosed |