Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 15/20 | 0.69 |
| ▸ | PRKDC | P78527 | 6/20 | 0.69 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 3/20 | 0.51 |
| ▸ | NEK2 | P51955 | 1/20 | 0.51 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.51 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.51 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.50 |
| ▸ | PARP1 | P09874 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11907360 | 0.88 | ATR (0.70) | ATRPRKDCATMNEK2CHEK1 | |
| SCHEMBL5684569 | 0.87 | ATR (0.63) | ATRPRKDCATMCDK5CDK5R1 | |
| SCHEMBL8306689 | 0.84 | ATR (0.67) | ATRPRKDCATMCDK5CDK5R1 | |
| SCHEMBL2484387 | 0.82 | ATR (1.00) | ATRPRKDCATM | |
| SCHEMBL13912898 | 0.80 | MAPK14 (0.46) | ATRPRKDCRXFP1ATMCDK5 | |
| SCHEMBL3460862 | 0.80 | ATR (0.72) | ATRPRKDCATM | |
| SCHEMBL557954 | 0.79 | ATR (0.72) | ATRPRKDCATM | |
| SCHEMBL3462566 | 0.77 | ATR (0.66) | ATRPRKDCATM | |
| SCHEMBL14067883 | 0.77 | ATR (0.60) | ATRPRKDCATM | |
| SCHEMBL318797 | 0.76 | ATR (0.68) | ATRPRKDCATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0914318-A1 | PYRAZINES | KINGS COLLEGE LONDON (GB) | 1999-05-12 | — | — | EP | disclosed |
| EP-0904272-A1 | DIHYDROBENZOFURAN AND RELATED COMPOUNDS USEFUL AS ANTI-INFLAMMATORY AGENTS | THE PROCTER & GAMBLE COMPANY (US) | 1999-03-31 | — | — | EP | disclosed |
| WO-1997043267-A1 | PYRAZINES | KINGS COLLEGE LONDON (GB) | 1997-11-20 | — | — | WO | disclosed |
| WO-1997028155-A1 | DIHYDROBENZOFURAN AND RELATED COMPOUNDS USEFUL AS ANTI-INFLAMMATORY AGENTS | THE PROCTER & GAMBLE COMPANY (US) | 1997-08-07 | — | — | WO | disclosed |