Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 6/20 | 0.46 |
| ▸ | CTSS | P25774 | 5/20 | 0.46 |
| ▸ | PPARA | Q07869 | 3/20 | 0.43 |
| ▸ | PPARG | P37231 | 2/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | KLK7 | P49862 | 2/20 | 0.39 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | ACE | P12821 | 1/20 | 0.37 |
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
| ▸ | CTSB | P07858 | 1/20 | 0.37 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17457748 | 1.00 | CTSK (0.46) | CTSKCTSSPPARAPPARGHDAC4 | |
| SCHEMBL1195750 | 1.00 | CTSK (0.46) | CTSKCTSSPPARAPPARGHDAC4 | |
| SCHEMBL15879598 | 0.89 | CTSK (0.42) | CTSKCTSSHDAC4HDAC1HDAC6 | |
| SCHEMBL17471221 | 0.89 | CTSK (0.42) | CTSKCTSSHDAC4HDAC1HDAC6 | |
| SCHEMBL8584214 | 0.85 | SMN1; SMN2 (0.39) | CTSKCTSSKMT2AMEN1 | |
| SCHEMBL2780551 | 0.83 | CTSS (0.51) | CTSKCTSSPPARAPPARGHDAC4 | |
| SCHEMBL2780552 | 0.83 | CTSS (0.51) | CTSKCTSSPPARAPPARGHDAC4 | |
| SCHEMBL31407349 | 0.83 | CTSS (0.51) | CTSKCTSSPPARAPPARGHDAC4 | |
| SCHEMBL29855068 | 0.82 | MEN1 (0.40) | KMT2AMEN1 | |
| SCHEMBL17471219 | 0.82 | CTSK (0.38) | CTSKCTSSHDAC4HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0710661-B1 | Amino acid derivative having anti-CKK activity | TOBISHI PHARMACEUTICAL CO (JP) | 1999-03-31 | — | — | EP | disclosed |
| US-5716958-A | GASTROINTESTINAL DISORDERS; INHIBITORY ACTIVITY ON CHOLECYSTOKININ | TOBISHI PHARMACEUTICAL CO., LTD. (JP) | 1998-02-10 | — | — | US | disclosed |
| EP-0710661-A1 | Amino acid derivative having anti-CKK activity | TOBISHI PHARMACEUTICAL CO., LTD. (JP) | 1996-05-08 | — | — | EP | disclosed |