SCHEMBL8306931

SCHEMBL8306931

CCc1n[nH]c(O)c1C(=O)c1ccc(S(C)(=O)=O)c(-c2ccc(C(F)(F)F)cc2)c1C

nearest known ligand 0.40

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
HEXA P06865 1/20 0.34
HEXB P07686 1/20 0.34
MAPT P10636 2/20 0.34
ALDH1A1 P00352 1/20 0.34
SNCA P37840 2/20 0.32
PTGS2 P35354 2/20 0.31
GSK3B P49841 1/20 0.31
KDM4E B2RXH2 1/20 0.31
MEN1 O00255 1/20 0.31
HSP90AA1 P07900 1/20 0.31
CRHBP P24387 1/20 0.31
KMT2A Q03164 1/20 0.31
CRHR2 Q13324 1/20 0.31
POLB P06746 1/20 0.31
PDE2A O00408 1/20 0.31
CRHR1 P34998 1/20 0.31
P2RX7 Q99572 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8302118 0.89 DPP4 (0.35) HEXAHEXBALDH1A1KMT2APOLB
SCHEMBL8300843 0.89 GSK3B (0.34) PTGS2GSK3BPOLB
SCHEMBL8301326 0.88 CA12 (0.35) ALDH1A1
SCHEMBL8301544 0.88 GHSR (0.34) PTGS2
SCHEMBL8301349 0.87 MEN1 (0.34) HEXAHEXBMAPTALDH1A1PTGS2
SCHEMBL8300662 0.87 MAPT (0.38) HEXAHEXBMAPTALDH1A1KDM4E
SCHEMBL15650113 0.83 CACNA1B (0.36) MAPTALDH1A1GSK3BKDM4ECRHR1
SCHEMBL8303758 0.82 HEXA (0.35) HEXAHEXBMEN1KMT2APOLB
SCHEMBL8305579 0.82 MAPT (0.33) MAPTALDH1A1KDM4EPOLB
SCHEMBL7807452 0.81 PIK3CA (0.32)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0914317-A2 1-ALKYL-4-BENZOYL-5-HYDROXYPYRAZOLE COMPOUNDS AND THEIR USE AS HERBICIDES Dow AgroSciences LLC (US) 1999-05-12 EP disclosed
WO-1998052926-A2 1-ALKYL-4-BENZOYL-5-HYDROXYPYRAZOLE COMPOUNDS AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 1998-11-26 WO disclosed