Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.41 |
| ▸ | HTR1B | P28222 | 3/20 | 0.39 |
| ▸ | EDNRB | P24530 | 1/20 | 0.39 |
| ▸ | EDNRA | P25101 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.38 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.38 |
| ▸ | HTR1D | P28221 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7228467 | 0.81 | KDM4E (0.54) | CREBBPKDM4EHPGDKDRALDH1A1 | |
| SCHEMBL7467297 | 0.77 | HPGD (0.43) | KDM4EHPGDKDRALDH1A1MRGPRX1 | |
| SCHEMBL8307237 | 0.76 | AR (0.56) | HPGDKDRMAPTMRGPRX1AR | |
| SCHEMBL7222716 | 0.71 | MRGPRX1 (0.54) | HPGDKDRMAPTMRGPRX1AR | |
| SCHEMBL7222256 | 0.71 | BRD4 (0.47) | KDM4EHPGDKDRALDH1A1MRGPRX1 | |
| SCHEMBL7220116 | 0.70 | BCL2L1 (0.48) | KDRALDH1A1ARBRD4 | |
| SCHEMBL7226423 | 0.69 | MRGPRX1 (0.45) | KDRMRGPRX1ARBRD4 | |
| SCHEMBL7221513 | 0.69 | BRD4 (0.45) | KDM4EHPGDKDRALDH1A1MRGPRX1 | |
| SCHEMBL9447062 | 0.69 | GLO1 (0.57) | KDM4EALDH1A1GAAMRGPRX1 | |
| SCHEMBL20372839 | 0.69 | KDM4E (0.61) | KDM4EHPGDALDH1A1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0966436-A1 | ARYL SULFONAMIDES AND ANALOGUES THEREOF AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | Bayer Aktiengesellschaft (DE) | 1999-12-29 | — | — | EP | disclosed |
| WO-1998037061-A1 | ARYL SULFONAMIDES AND ANALOGUES THEREOF AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | BAYER AKTIENGESELLSCHAFT (DE) | 1998-08-27 | — | — | WO | disclosed |