Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 1/20 | 0.56 |
| ▸ | MRGPRX1 | Q96LB2 | 3/20 | 0.55 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.48 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.48 |
| ▸ | PGR | P06401 | 2/20 | 0.47 |
| ▸ | BRD4 | O60885 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MITF | O75030 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.43 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7228204 | 0.83 | PGR (0.51) | ARBCL2L1MCL1PGRLMNA | |
| SCHEMBL7219583 | 0.83 | AR (0.51) | ARMRGPRX1BCL2L1MCL1BRD4 | |
| SCHEMBL7227793 | 0.82 | MRGPRX1 (0.45) | MRGPRX1BCL2L1MCL1LMNAMEN1 | |
| SCHEMBL7222716 | 0.82 | MRGPRX1 (0.54) | ARMRGPRX1BRD4LMNAMEN1 | |
| SCHEMBL7222256 | 0.82 | BRD4 (0.47) | ARMRGPRX1BCL2L1MCL1BRD4 | |
| SCHEMBL7221201 | 0.82 | AR (0.47) | ARMRGPRX1BCL2L1MCL1BRD4 | |
| SCHEMBL9447116 | 0.81 | AR (0.52) | ARMRGPRX1LMNAHPGDMAPT | |
| SCHEMBL7220116 | 0.81 | BCL2L1 (0.48) | ARBCL2L1MCL1BRD4LMNA | |
| SCHEMBL7220099 | 0.81 | BCL2L1 (0.48) | BCL2L1MCL1PGRLMNAMEN1 | |
| SCHEMBL7460395 | 0.81 | BCL2L1 (0.51) | BCL2L1MCL1PGRLMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0966436-A1 | ARYL SULFONAMIDES AND ANALOGUES THEREOF AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | Bayer Aktiengesellschaft (DE) | 1999-12-29 | — | — | EP | disclosed |
| WO-1998037061-A1 | ARYL SULFONAMIDES AND ANALOGUES THEREOF AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | BAYER AKTIENGESELLSCHAFT (DE) | 1998-08-27 | — | — | WO | disclosed |