Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 11/20 | 0.43 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.43 |
| ▸ | XDH | P47989 | 1/20 | 0.43 |
| ▸ | IPMK | Q8NFU5 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | IP6K2 | Q9UHH9 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | TOP2A | P11388 | 2/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4575953 | 1.00 | PPARG (0.43) | PPARGEGFRCYP1B1KDM1ACYP1A1 | |
| SCHEMBL4575957 | 1.00 | PPARG (0.43) | PPARGEGFRCYP1B1KDM1ACYP1A1 | |
| SCHEMBL4575775 | 0.90 | CYP1B1 (0.46) | PPARGEGFRCYP1B1KDM1ACYP1A1 | |
| SCHEMBL4575066 | 0.90 | CYP1B1 (0.46) | PPARGEGFRCYP1B1KDM1ACYP1A1 | |
| SCHEMBL4574734 | 0.90 | CYP1B1 (0.46) | PPARGEGFRCYP1B1KDM1ACYP1A1 | |
| SCHEMBL8305425 | 0.84 | MAOB (0.53) | EGFRCYP1B1KDM1ACYP1A1CYP1A2 | |
| SCHEMBL8309780 | 0.84 | BRD4 (0.46) | TOP2AMAOA | |
| SCHEMBL8427180 | 0.84 | XDH (0.55) | PPARGEGFRXDHRETKDR | |
| SCHEMBL8308340 | 0.83 | BRD4 (0.43) | CYP1A2TOP2AMAOA | |
| SCHEMBL8427202 | 0.83 | KDM4E (0.54) | PPARGEGFRCYP1A2RETKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0709383-B1 | Diosmetin derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1999-12-15 | — | — | EP | disclosed |
| US-5629339-A | CHRONIC VENOUS INSUFFICIENCY | ADIR ET COMPAGNIE (FR) | 1997-05-13 | — | — | US | disclosed |
| EP-0709383-A1 | Diosmetin derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-05-01 | — | — | EP | disclosed |