Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 14/20 | 0.38 |
| ▸ | DRD3 | P35462 | 10/20 | 0.38 |
| ▸ | DRD4 | P21917 | 9/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 3/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 4/20 | 0.35 |
| ▸ | HTR1D | P28221 | 2/20 | 0.33 |
| ▸ | HTR1B | P28222 | 2/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8302748 | 0.91 | DRD2 (0.39) | DRD2DRD3DRD4PARP1HTR2A | |
| SCHEMBL8301874 | 0.85 | DRD2 (0.37) | DRD2DRD3DRD4HTR2ADRD1 | |
| SCHEMBL8303055 | 0.82 | DRD2 (0.37) | DRD2DRD3DRD4HTR2ADRD1 | |
| SCHEMBL8301738 | 0.82 | PARP1 (0.39) | DRD2DRD3DRD4PARP1HTR2A | |
| SCHEMBL8307985 | 0.81 | DRD2 (0.34) | DRD2HTR1A | |
| SCHEMBL8307617 | 0.76 | PARP1 (0.45) | DRD2DRD3DRD4PARP1HTR1A | |
| SCHEMBL8303332 | 0.76 | PARP1 (0.45) | DRD2DRD3DRD4PARP1NR3C2 | |
| SCHEMBL8308384 | 0.76 | DRD2 (0.37) | DRD2DRD3DRD4PARP1HTR2A | |
| SCHEMBL8306164 | 0.72 | DRD2 (0.33) | DRD2DRD3HTR1A | |
| SCHEMBL8304724 | 0.71 | DRD2 (0.34) | DRD2DRD3DRD4PARP1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0548254-B1 | 6- OR 7-(IMIDAZOLIDIN-2-YLIDENEAMINO)-1,4-BENZOXAZINES AS ALPHA ADRENERGIC AGENTS | ALLERGAN INC (US) | 1999-06-02 | — | — | EP | disclosed |
| EP-0548254-A1 | 6- or 7- (2-IMINO-2-IMIDAZOLIDINE)-1,4-BENZOXAZINES AS ALPHA ADRENERGIC AGENTS | ALLERGAN, INC. (US) | 1993-06-30 | — | — | EP | disclosed |
| WO-1992004345-A1 | 6- or 7- (2-IMINO-2-IMIDAZOLIDINE)-1,4-BENZOXAZINES AS ALPHA ADRENERGIC AGENTS | ALLERGAN, INC. (US) | 1992-03-19 | — | — | WO | disclosed |
| US-5091528-A | Antiglaucoma, antidiarrhea agents, diuretics, vasoconstrictors | ALLERGAN, INC. (US) | 1992-02-25 | — | — | US | disclosed |