Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.34 |
| ▸ | DRD3 | P35462 | 5/20 | 0.34 |
| ▸ | DRD4 | P21917 | 5/20 | 0.34 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.31 |
| ▸ | DRD1 | P21728 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.30 |
| ▸ | CCR1 | P32246 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8301738 | 0.87 | PARP1 (0.39) | DRD2DRD3DRD4NR3C2DRD1 | |
| SCHEMBL8308384 | 0.85 | DRD2 (0.37) | DRD2DRD3DRD4NR3C2DRD1 | |
| SCHEMBL8304731 | 0.82 | — | — | |
| SCHEMBL8308168 | 0.81 | DRD2 (0.37) | DRD2DRD3DRD4NR3C2HTR2A | |
| SCHEMBL8305470 | 0.81 | NR3C2 (0.44) | DRD2DRD3DRD4NR3C2HTR2A | |
| SCHEMBL8301771 | 0.76 | NR3C2 (0.37) | NR3C2PARP1CCR1KCNH2CYP3A4 | |
| SCHEMBL8301805 | 0.76 | PARP1 (0.35) | DRD2DRD3DRD4NR3C2PARP1 | |
| SCHEMBL8304614 | 0.76 | PARP1 (0.35) | DRD2DRD3DRD4NR3C2HTR2A | |
| SCHEMBL8307023 | 0.71 | DRD2 (0.38) | DRD2DRD3DRD4NR3C2DRD1 | |
| SCHEMBL8303552 | 0.70 | DRD2 (0.33) | DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0548254-B1 | 6- OR 7-(IMIDAZOLIDIN-2-YLIDENEAMINO)-1,4-BENZOXAZINES AS ALPHA ADRENERGIC AGENTS | ALLERGAN INC (US) | 1999-06-02 | — | — | EP | disclosed |
| US-5091528-A | Antiglaucoma, antidiarrhea agents, diuretics, vasoconstrictors | ALLERGAN, INC. (US) | 1992-02-25 | — | — | US | disclosed |