Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 5/20 | 0.45 |
| ▸ | DDB1 | Q16531 | 4/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 4/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8306896 | 0.80 | CRBN (0.50) | CRBNDDB1CA2PPARGALDH1A1 | |
| SCHEMBL8304222 | 0.73 | CA2 (0.50) | CRBNDDB1CA2SMN1; SMN2PPARG | |
| SCHEMBL22623731 | 0.62 | CRBN (1.00) | CRBNDDB1 | |
| SCHEMBL1249983 | 0.60 | PPARG (0.51) | PPARGKDM4EMAPK1 | |
| SCHEMBL8302470 | 0.59 | CA2 (0.39) | CRBNDDB1CA2SMN1; SMN2PPARG | |
| SCHEMBL21047745 | 0.57 | CRBN (0.49) | CRBNDDB1SMN1; SMN2ALDH1A1HTT | |
| SCHEMBL7109117 | 0.56 | LMNA (0.38) | SMN1; SMN2ALDH1A1KDM4ETSHRHTT | |
| SCHEMBL25241776 | 0.55 | KDM4E (0.42) | CRBNDDB1SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL25280130 | 0.55 | KDM4E (0.42) | CRBNDDB1SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL25280131 | 0.55 | KDM4E (0.42) | CRBNDDB1SMN1; SMN2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0749430-B1 | THIAZOLIDINEDIONE DERIVATIVES AS ANTI-HYPERGLYCEMIC AGENTS | AMERICAN HOME PROD (US) | 1999-08-25 | — | — | EP | disclosed |
| US-5605918-A | SUBSTITUTED THIAZOLIDINE-2,4-DIONES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-02-25 | — | — | US | disclosed |
| EP-0749430-A1 | THIAZOLIDINEDIONE DERIVATIVES AS ANTI-HYPERGLYCEMIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-12-27 | — | — | EP | disclosed |
| US-5574051-A | HYPOGLYCEMIC | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-11-12 | — | — | US | disclosed |
| WO-1995024400-A1 | THIAZOLIDINEDIONE DERIVATIVES AS ANTI-HYPERGLYCEMIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-09-14 | — | — | WO | disclosed |