Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | TNKS | O95271 | 1/20 | 0.37 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 8/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8305151 | 0.83 | PARP1 (0.54) | PARP1PIM1CSNK1D | |
| SCHEMBL1855116 | 0.69 | ALDH1A1 (0.61) | LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL10472517 | 0.65 | TDP1 (0.51) | LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL581225 | 0.63 | TDP1 (0.49) | LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL30101115 | 0.62 | PDE4A (0.47) | KDM4ELMNAALDH1A1HPGDTNKS | |
| SCHEMBL31014280 | 0.62 | NPSR1 (0.62) | KDM4ELMNAALDH1A1HPGDNPSR1 | |
| SCHEMBL19678716 | 0.62 | ALDH1A1 (0.54) | LMNAALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL16672928 | 0.62 | TDP1 (0.54) | LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL6181708 | 0.61 | ALDH1A1 (0.58) | LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL31110163 | 0.61 | ALDH1A1 (0.58) | LMNAALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004105700-A2 | COMPOUNDS, METHODS AND PHARMACEUTICAL COMPOSITIONS FOR INHIBITING PARP | GUILDFORD PHARMACEUTICALS, INC. (US) | 2004-12-09 | — | — | WO | disclosed |