Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 17/20 | 0.50 |
| ▸ | LTA4H | P09960 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8306646 | 0.87 | TBXAS1 (0.64) | TBXAS1 | |
| SCHEMBL8307374 | 0.85 | TBXAS1 (0.48) | TBXAS1LTA4H | |
| SCHEMBL8308276 | 0.84 | TBXAS1 (0.49) | TBXAS1 | |
| SCHEMBL8701897 | 0.82 | TBXAS1 (0.49) | TBXAS1 | |
| SCHEMBL8309308 | 0.81 | TBXAS1 (0.60) | TBXAS1 | |
| SCHEMBL29059890 | 0.81 | TBXAS1 (0.51) | TBXAS1CYP3A4 | |
| SCHEMBL8707366 | 0.80 | TBXAS1 (0.48) | TBXAS1LTA4H | |
| SCHEMBL6642234 | 0.80 | TBXAS1 (0.60) | TBXAS1LTA4H | |
| SCHEMBL5262346 | 0.77 | SIRT2 (0.49) | — | |
| SCHEMBL64891 | 0.77 | TBXAS1 (0.59) | TBXAS1LTA4HCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0579618-B1 | PYRIDINE- AND IMIDAZOLE-DERIVED AGENTS FOR CARDIOVASCULAR DISEASES | PFIZER LTD (GB) | 1999-10-13 | — | — | EP | disclosed |
| US-5705523-A | THROMBOXANE A2 SYNTHETASE INHIBITORS | PFIZER INC. (US) | 1998-01-06 | — | — | US | disclosed |
| US-5457118-A | Pyridine derived agents for cardiovascular diseases | PFIZER INC. (US) | 1995-10-10 | — | — | US | disclosed |