Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.66 |
| ▸ | RAB9A | P51151 | 3/20 | 0.66 |
| ▸ | POLB | P06746 | 2/20 | 0.66 |
| ▸ | PKM | P14618 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | TP53 | P04637 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | HTT | P42858 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | KDR | P35968 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9389382 | 0.89 | MAPT (0.66) | NPC1RAB9APOLBPKMALDH1A1 | |
| SCHEMBL13862605 | 0.83 | MAPT (0.56) | NPC1RAB9APOLBPKMALDH1A1 | |
| SCHEMBL11612838 | 0.80 | ALDH1A1 (0.62) | NPC1RAB9APOLBPKMALDH1A1 | |
| SCHEMBL28335130 | 0.80 | KMT2A (0.63) | NPC1RAB9APKMALDH1A1MAPT | |
| SCHEMBL6314599 | 0.79 | MAPK1 (0.68) | NPC1RAB9APOLBPKMALDH1A1 | |
| SCHEMBL23406613 | 0.78 | RAB9A (0.54) | NPC1RAB9APOLBPKMALDH1A1 | |
| SCHEMBL8618810 | 0.78 | ALDH1A1 (1.00) | NPC1RAB9APOLBALDH1A1TP53 | |
| SCHEMBL8305769 | 0.77 | RAB9A (0.49) | NPC1RAB9APOLBPKMALDH1A1 | |
| SCHEMBL28337455 | 0.77 | GRM4 (0.60) | NPC1RAB9APOLBPKMALDH1A1 | |
| SCHEMBL28337424 | 0.77 | RAB9A (0.53) | NPC1RAB9APOLBPKMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0790986-B1 | ANILINE DERIVATIVES | ZENECA LTD (GB) | 1999-01-20 | — | — | EP | disclosed |
| US-5821246-A | USEFUL AS TYROSINE KINASE INHIBITORS AND FOR THE TREATMENT OF PROLIFERATIVE DISEASES SUCH AS CANCER | ZENECA LIMITED (GB) | 1998-10-13 | — | — | US | disclosed |
| EP-0790986-A1 | ANILINE DERIVATIVES | ZENECA LIMITED (GB) | 1997-08-27 | — | — | EP | disclosed |
| WO-1996015118-A1 | ANILINE DERIVATIVES | ZENECA LIMITED (GB) | 1996-05-23 | — | — | WO | disclosed |