Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 13/20 | 0.74 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.74 |
| ▸ | TSHR | P16473 | 2/20 | 0.74 |
| ▸ | POLB | P06746 | 2/20 | 0.70 |
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.65 |
| ▸ | USP2 | O75604 | 1/20 | 0.65 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.65 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.64 |
| ▸ | PKM | P14618 | 2/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6852418 | 0.98 | KDM4E (0.76) | KDM4EHSD17B10ALDH1A1TSHRPOLB | |
| SCHEMBL27979659 | 0.92 | KDM4E (0.85) | KDM4EHSD17B10ALDH1A1TSHRPOLB | |
| SCHEMBL2677273 | 0.86 | KDM4E (0.63) | KDM4EHSD17B10ALDH1A1TSHRPOLB | |
| SCHEMBL4729693 | 0.85 | KDM4E (0.59) | KDM4EHSD17B10ALDH1A1TSHRPOLB | |
| SCHEMBL1574588 | 0.85 | KDM4E (0.62) | KDM4EHSD17B10ALDH1A1TSHRPOLB | |
| SCHEMBL1575064 | 0.85 | KDM4E (0.62) | KDM4EHSD17B10ALDH1A1TSHRPOLB | |
| SCHEMBL2384053 | 0.85 | KDM4E (0.70) | KDM4EHSD17B10ALDH1A1TSHRPOLB | |
| SCHEMBL20887176 | 0.85 | KDM4E (0.70) | KDM4EHSD17B10ALDH1A1TSHRPOLB | |
| SCHEMBL1623839 | 0.85 | KDM4E (1.00) | KDM4EHSD17B10ALDH1A1TSHRPOLB | |
| SCHEMBL2677588 | 0.85 | KDM4E (0.68) | KDM4EHSD17B10ALDH1A1TSHRPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019071104-A1 | COMPOSITIONS AND METHODS FOR PREVENTION AND TREATMENT OF HYPERAMMONEMIA | CHILDREN'S NATIONAL MEDICAL CENTER (US) | 2019-04-11 | — | — | WO | disclosed |
| US-8143257-B2 | inhibiting angiogenesis; cancer, diabetic retinopathy, rheumatoid arthritis, psoriasis, atherosclerosis, obesity, chronic inflammation or exudative macular degeneration; 4-(Hydroxy-diphenyl-methyl)-piperidine-1-carboxylic acid 1-bromo-naphthalen-2-yl ester | PTC THERAPEUTICS, INC. (US) | 2012-03-27 | — | — | US | disclosed |