Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 15/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.70 |
| ▸ | TSHR | P16473 | 1/20 | 0.70 |
| ▸ | POLB | P06746 | 3/20 | 0.67 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | USP2 | O75604 | 1/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.61 |
| ▸ | PKM | P14618 | 1/20 | 0.61 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5492081 | 0.99 | KDM4E (0.68) | KDM4EALDH1A1HSD17B10TSHRPOLB | |
| SCHEMBL27979659 | 0.89 | KDM4E (0.85) | KDM4EALDH1A1HSD17B10TSHRPOLB | |
| SCHEMBL6852418 | 0.86 | KDM4E (0.76) | KDM4EALDH1A1HSD17B10TSHRPOLB | |
| SCHEMBL830750 | 0.85 | KDM4E (0.74) | KDM4EALDH1A1HSD17B10TSHRPOLB | |
| SCHEMBL4729693 | 0.82 | KDM4E (0.59) | KDM4EALDH1A1HSD17B10TSHRPOLB | |
| SCHEMBL2656688 | 0.82 | KDM4E (0.62) | KDM4EALDH1A1HSD17B10TSHRPOLB | |
| SCHEMBL1623839 | 0.82 | KDM4E (1.00) | KDM4EALDH1A1HSD17B10TSHRPOLB | |
| SCHEMBL20887176 | 0.82 | KDM4E (0.70) | KDM4EALDH1A1HSD17B10TSHRPOLB | |
| SCHEMBL20886934 | 0.80 | POLB (0.55) | KDM4EALDH1A1HSD17B10TSHRPOLB | |
| SCHEMBL20886952 | 0.80 | POLB (0.55) | KDM4EALDH1A1HSD17B10TSHRPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8013156-B2 | Tie-2 modulators and methods of use | EXELIXIS, INC. (US) | 2011-09-06 | — | — | US | disclosed |
| US-20070275952-A1 | Tie-2 Modulators and Methods of Use | EXELIXIS, INC. (US) | 2007-11-29 | — | — | US | disclosed |
| US-20060211707-A1 | Piperazine-alkyl-ureido derivatives | ACTELION PHARMACEUTICALS LTD. (CH) | 2006-09-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060211707-A1 | Piperazine-alkyl-ureido derivatives | ADRA2C, UTS2R, ADRB2 | KDM4E 1924/4885ALDH1A1 2026/4885HSD17B10 4289/4885 |
| US-20070275952-A1 | Tie-2 Modulators and Methods of Use | TIE1, TEK, KDR | KDM4E 486/4885ALDH1A1 3053/4885HSD17B10 3740/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.