Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 2/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.44 |
| ▸ | HTR1A | P08908 | 2/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | GBA1 | P04062 | 1/20 | 0.43 |
| ▸ | TACR1 | P25103 | 1/20 | 0.43 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.43 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20015572 | 0.93 | MAOB (0.48) | MAOBSLC6A4SLC6A2SLC6A3HTR1A | |
| SCHEMBL9093168 | 0.89 | HRH3 (0.49) | MAOBHRH3 | |
| SCHEMBL4319526 | 0.89 | TACR1 (0.50) | MAOBSLC6A4SLC6A2SLC6A3HTR1A | |
| Hydrochloric Acid SCHEMBL5764206 | 0.88 | TACR1 (0.49) | MAOBSLC6A4SLC6A2SLC6A3HTR1A | |
| Trifluoroacetic Acid SCHEMBL19994597 | 0.88 | ITGB3 (0.50) | MAOBSLC6A4SLC6A2SLC6A3TACR1 | |
| SCHEMBL3716138 | 0.86 | MAOB (0.60) | MAOB | |
| SCHEMBL18715291 | 0.82 | MAOB (0.57) | MAOB | |
| SCHEMBL9562394 | 0.82 | MAOB (0.55) | MAOBSLC6A4SLC6A2HRH3TACR1 | |
| SCHEMBL1199744 | 0.81 | MAOB (0.53) | MAOBSLC6A4SLC6A2SLC6A3HRH3 | |
| SCHEMBL4244293 | 0.81 | MAOB (0.53) | MAOBSLC6A4SLC6A2HRH3GBA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018055096-A1 | DISUBTITUTED AZETIDINES, PYRROLIDINES, PIPERIDINES AND AZEPANES AS INHIBITORS OF MONOAMINE OXIDASE B FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | UNIVERSITY OF LJUBLJANA (SI) | 2018-03-29 | — | — | WO | disclosed |
| EP-3290416-A1 | SUBSTITUTED N-[2-(4-PHENOXYPIPERIDIN-1-YL)-2-(1,3-THIAZOL-5-YL)ETHYL]BENZAMIDE AND N-[2-(4-BENZYLOXYPIPERIDIN-1-YL)-2-(1,3-THIAZOL-5-YL)ETHYL]BENZAMIDE DERIVATIVES AND THEIR USE AS P2X7 RECEPTOR ANTAGONIST | AXXAM S.p.A. (IT) | 2018-03-07 | — | — | EP | disclosed |
| CN-102459248-A | Benzoxepin as PI3K/mTOR inhibitors and methods of their use and manufacture | EXELIXIS INC | 2012-05-16 | — | — | CN | disclosed |
| CN-1989127-A | Kynurenic acid amide derivatives as NR2B receptor antagonists | RICHTER GEDEON VEGYESZET (HU) | 2007-06-27 | — | — | CN | disclosed |
| EP-0929550-A1 | $i(N)-(BENZOTHIAZOL-2-YL) PIPERIDINE-1-ETHANAMINE DERIVATIVES, THEIR PREPARATION AND APPLICATION IN THERAPEUTICS | SYNTHELABO (FR) | 1999-07-21 | — | — | EP | disclosed |
| WO-1998014444-A1 | N-(BENZOTHIAZOL-2-YL) PIPERIDINE-1-ETHANAMINE DERIVATIVES, THEIR PREPARATION AND APPLICATION IN THERAPEUTICS | SYNTHELABO (FR) | 1998-04-09 | — | — | WO | disclosed |
| EP-0604494-A1 | 5-HT 4? RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-07-06 | — | — | EP | disclosed |
| CN-1069491-A | 2-(piperidines-1-yl) alcohol derivative, its method for making and treatment thereof are used | SYNTHELABO (FR) | 1993-03-03 | — | — | CN | disclosed |
| EP-0524846-A1 | 2-(Piperidin-1-yl)ethanol derivatives, their preparation and their use in therapeutics | SYNTHELABO (FR) | 1993-01-27 | — | — | EP | disclosed |
| US-4077958-A | ANTIDEPRESSANTS | E. R. SQUIBB & SONS, INC. (US) | 1978-03-07 | — | — | US | disclosed |
| US-4007191-A | ANTIDEPRESSANT | E. R. SQUIBB & SONS, INC. (US) | 1977-02-08 | — | — | US | disclosed |
| US-3935227-A | ANTIDEPRESSANTS, ANTIANXIETY, ANTIINFLAMMATORY AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1976-01-27 | — | — | US | disclosed |