Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 6/20 | 0.58 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | MAP3K8 | P41279 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8312604 | 0.89 | EGFR (0.61) | EGFRIRAK4CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8312988 | 0.78 | EGFR (0.57) | EGFRCYP1A2CYP3A4CYP2D6CLK4 | |
| SCHEMBL4780623 | 0.78 | CYP1A2 (0.59) | IRAK4CYP1A2CYP3A4CYP2D6CLK4 | |
| SCHEMBL4468260 | 0.77 | EGFR (0.60) | EGFRCYP1A2CYP3A4CYP2D6CLK4 | |
| SCHEMBL8311954 | 0.77 | CLK1 (0.46) | IRAK4CLK4HSD17B10ALDH1A1LMNA | |
| SCHEMBL18359127 | 0.76 | EGFR (0.70) | EGFRMAP3K8 | |
| SCHEMBL8312573 | 0.75 | EGFR (0.52) | EGFR | |
| SCHEMBL6364052 | 0.73 | IRAK4 (0.47) | EGFRIRAK4 | |
| SCHEMBL18359136 | 0.72 | EGFR (0.73) | EGFRCYP1A2CYP3A4CYP2D6CLK4 | |
| SCHEMBL6368598 | 0.71 | IRAK4 (0.48) | EGFRIRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005016925-A1 | AZAQUINAZOLINE DERIVATIVES | PFIZER LIMITED (GB) | 2005-02-24 | — | — | WO | disclosed |