Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 6/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.48 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | MAP3K8 | P41279 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8307974 | 0.89 | EGFR (0.58) | EGFRCYP1A2CYP3A4CYP2D6CLK4 | |
| SCHEMBL4780623 | 0.88 | CYP1A2 (0.59) | CYP1A2CYP3A4CYP2D6CLK4IRAK4 | |
| SCHEMBL8312573 | 0.85 | EGFR (0.52) | EGFRMEN1KMT2A | |
| SCHEMBL8312988 | 0.82 | EGFR (0.57) | EGFRCYP1A2CYP3A4CYP2D6CLK4 | |
| SCHEMBL6368598 | 0.82 | IRAK4 (0.48) | EGFRIRAK4 | |
| SCHEMBL8306375 | 0.80 | GRM1 (0.49) | — | |
| SCHEMBL8312990 | 0.80 | MEN1 (0.44) | IRAK4MEN1KMT2A | |
| SCHEMBL4468260 | 0.79 | EGFR (0.60) | EGFRCYP1A2CYP3A4CYP2D6CLK4 | |
| SCHEMBL8306177 | 0.78 | GRM1 (0.55) | EGFR | |
| SCHEMBL18359127 | 0.77 | EGFR (0.70) | EGFRMAP3K8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005016925-A1 | AZAQUINAZOLINE DERIVATIVES | PFIZER LIMITED (GB) | 2005-02-24 | — | — | WO | disclosed |