Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | NPC1 | O15118 | 3/20 | 0.60 |
| ▸ | RAB9A | P51151 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | CNR1 | P21554 | 1/20 | 0.58 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.55 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 8/20 | 0.54 |
| ▸ | CA12 | O43570 | 2/20 | 0.51 |
| ▸ | CA1 | P00915 | 2/20 | 0.51 |
| ▸ | CA2 | P00918 | 2/20 | 0.51 |
| ▸ | CA9 | Q16790 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8306238 | 0.88 | CDK5 (0.60) | MEN1NPC1RAB9AKMT2AKDM4E | |
| SCHEMBL8306286 | 0.84 | CDK5 (0.56) | MEN1NPC1RAB9AKMT2AKDM4E | |
| SCHEMBL8444391 | 0.82 | CDK5 (0.55) | CDK5CDK5R1PTGS2CA12CA1 | |
| SCHEMBL7662705 | 0.82 | KMT2A (0.79) | MEN1NPC1RAB9AKMT2AKDM4E | |
| SCHEMBL8305443 | 0.80 | CA12 (0.72) | MEN1NPC1RAB9AKMT2AKDM4E | |
| SCHEMBL28844907 | 0.80 | RAB9A (0.70) | MEN1NPC1RAB9AKMT2AKDM4E | |
| SCHEMBL2929691 | 0.77 | CDK5 (0.55) | ALDH1A1SMN1; SMN2CDK5CDK5R1PTGS2 | |
| SCHEMBL6585157 | 0.76 | MEN1 (0.70) | MEN1NPC1RAB9AKMT2AKDM4E | |
| SCHEMBL29804879 | 0.76 | MEN1 (0.70) | MEN1NPC1RAB9AKMT2AKDM4E | |
| SCHEMBL6988904 | 0.76 | CNR1 (0.58) | SMN1; SMN2CNR1PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0915848-A1 | 1,2-DIARYLINDOLE AS COX-2 INHIBITORS | LABORATOIRES UPSA (FR) | 1999-05-19 | — | — | EP | disclosed |
| US-5723485-A | ANALGESIC, ANTIINFLAMMATORY AGENTS | LABORATORIES UPSA (FR) | 1998-03-03 | — | — | US | disclosed |
| WO-1998005639-A1 | 1,2-DIARYLINDOLE AS COX-2 INHIBITORS | LABORATOIRES UPSA (FR) | 1998-02-12 | — | — | WO | disclosed |