Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 1/20 | 0.58 |
| ▸ | PTGS2 | P35354 | 8/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.50 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.50 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | DAO | P14920 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.40 |
| ▸ | F7 | P08709 | 1/20 | 0.39 |
| ▸ | F3 | P13726 | 1/20 | 0.39 |
| ▸ | IDH1 | O75874 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6826452 | 0.84 | LOXL2 (0.64) | LOXL2SIRT1SMN1; SMN2DAOPCSK9 | |
| SCHEMBL6989299 | 0.79 | LOXL2 (0.57) | CNR1LOXL2SIRT1SMN1; SMN2DAO | |
| SCHEMBL8802664 | 0.79 | LOXL2 (0.57) | LOXL2SIRT1SMN1; SMN2DAOPCSK9 | |
| SCHEMBL6824873 | 0.78 | LOXL2 (0.60) | LOXL2SIRT1SMN1; SMN2DAOPCSK9 | |
| SCHEMBL866136 | 0.77 | LOXL2 (0.72) | LOXL2SIRT1SMN1; SMN2DAOPCSK9 | |
| SCHEMBL12096730 | 0.77 | SIRT1 (0.56) | LOXL2SIRT1SMN1; SMN2DAOF7 | |
| SCHEMBL8308055 | 0.76 | MEN1 (0.60) | CNR1PTGS2PTGS1SMN1; SMN2 | |
| SCHEMBL6993553 | 0.76 | PTGS2 (0.50) | CNR1PTGS2PTGS1DAO | |
| SCHEMBL6994727 | 0.76 | LOXL2 (0.57) | LOXL2SIRT1SMN1; SMN2DAOPCSK9 | |
| SCHEMBL6824328 | 0.74 | LOXL2 (0.58) | LOXL2SIRT1SMN1; SMN2DAOPCSK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1322646-A1 | 2-(1H-INDOL-3-YL)-2-OXO-ACETIC ACID AMIDES WITH ANTITUMOR ACTIVITY | Novuspharma S.p.A. (IT) | 2003-07-02 | — | — | EP | disclosed |
| EP-1244652-A1 | 2-(1H-INDOL-3-YL)-2-OXO-ACETAMIDES WITH ANTITUMOR ACTIVITY | Cell Therapeutics Europe S.R.L. (IT) | 2002-10-02 | — | — | EP | disclosed |
| WO-2002008225-A1 | 2-(1H-INDOL-3-YL)-2-OXO-ACETIC ACID AMIDES WITH ANTITUMOR ACTIVITY | NOVUSPHARMA S.P.A. (IT) | 2002-01-31 | — | — | WO | disclosed |
| WO-2001047916-A1 | 2-(1H-INDOL-3-YL)-2-OXO-ACETAMIDES WITH ANTITUMOR ACTIVITY | NOVUSPHARMA S.P.A. (IT) | 2001-07-05 | — | — | WO | disclosed |