Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.55 |
| ▸ | JAK2 | O60674 | 16/20 | 0.54 |
| ▸ | JAK3 | P52333 | 10/20 | 0.54 |
| ▸ | JAK1 | P23458 | 6/20 | 0.54 |
| ▸ | TYK2 | P29597 | 4/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.54 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.54 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.52 |
| ▸ | PLK4 | O00444 | 2/20 | 0.51 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.51 |
| ▸ | CIT | O14578 | 1/20 | 0.51 |
| ▸ | GAK | O14976 | 1/20 | 0.51 |
| ▸ | OPA1 | O60313 | 1/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.51 |
| ▸ | STK16 | O75716 | 1/20 | 0.51 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14063781 | 0.92 | SYK (0.53) | SYKJAK2JAK3SMG1CDK2 | |
| SCHEMBL14021223 | 0.91 | JAK2 (0.64) | JAK2JAK3JAK1TYK2HDAC1 | |
| SCHEMBL8312552 | 0.89 | JAK2 (0.60) | SYKJAK2JAK3JAK1TYK2 | |
| SCHEMBL14021308 | 0.89 | JAK2 (0.55) | SYKJAK2JAK3JAK1TYK2 | |
| SCHEMBL4392408 | 0.87 | PIK3CA (0.51) | JAK2JAK3JAK1TYK2HDAC1 | |
| SCHEMBL14063782 | 0.87 | JAK2 (0.52) | JAK2JAK3JAK1TYK2HDAC1 | |
| SCHEMBL13590765 | 0.87 | JAK2 (0.51) | JAK2JAK3JAK1TYK2HDAC1 | |
| SCHEMBL14021327 | 0.85 | JAK2 (0.49) | JAK2JAK3JAK1TYK2HDAC1 | |
| SCHEMBL8312171 | 0.85 | IKBKB (0.54) | SYKJAK2JAK3JAK1TYK2 | |
| SCHEMBL14021080 | 0.85 | PIK3CA (0.52) | JAK2JAK3JAK1TYK2HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7429599-B2 | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-09-30 | — | — | US | disclosed |
| US-7429599-B2 | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-09-30 | — | — | US | disclosed |
| WO-2004084901-A1 | METHODS FOR TREATING OR PREVENTING AN INFLAMMATORY OR METABOLIC CONDITION BY INHIBITING JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2004-10-07 | — | — | WO | disclosed |