Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | TSHR | P16473 | 3/20 | 0.49 |
| ▸ | F2 | P00734 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.45 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.45 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18145 | 0.92 | TDP1 (0.63) | ALDH1A1TDP1MAPK1HIF1ASLC6A2 | |
| Ethyl Benzoate SCHEMBL28129225 | 0.81 | LMNA (0.61) | ALDH1A1TDP1MAPK1HIF1ASLC6A2 | |
| SCHEMBL6889633 | 0.81 | KDM4E (0.64) | ALDH1A1TDP1MAPK1HIF1ASLC6A2 | |
| SCHEMBL11059865 | 0.78 | ALDH1A1 (0.69) | ALDH1A1TDP1MAPK1HIF1ASLC6A2 | |
| SCHEMBL5925291 | 0.77 | TDP1 (0.65) | ALDH1A1TDP1MAPK1HIF1ASLC6A2 | |
| Benzoyl Peroxide SCHEMBL28111959 | 0.77 | LMNA (0.81) | ALDH1A1TDP1MAPK1HIF1ASLC6A2 | |
| SCHEMBL10837313 | 0.77 | ALDH1A1 (0.61) | ALDH1A1TDP1MAPK1HIF1ASLC6A2 | |
| SCHEMBL2747973 | 0.76 | TDP1 (0.70) | ALDH1A1TDP1MAPK1HIF1ASLC6A2 | |
| SCHEMBL10836995 | 0.76 | ALDH1A1 (0.65) | ALDH1A1TDP1MAPK1HIF1ASLC6A2 | |
| SCHEMBL11223386 | 0.76 | TDP1 (0.63) | ALDH1A1TDP1MAPK1HIF1ASLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5914339-A | ANTI-DIABETIC AND/OR ANTIHYPERGLYCEMIA AND/OR ANTI-OBESITY AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-06-22 | — | — | US | disclosed |
| EP-0901484-A1 | SUBSTITUTED 1, 3-BENZODIOXOLES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-03-17 | — | — | EP | disclosed |
| WO-1997043273-A1 | SUBSTITUTED 1, 3-BENZODIOXOLES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-11-20 | — | — | WO | disclosed |