Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADH1B | P00325 | 4/20 | 0.37 |
| ▸ | ADH1A | P07327 | 4/20 | 0.37 |
| ▸ | ADH7 | P40394 | 3/20 | 0.37 |
| ▸ | ADH1C | P00326 | 3/20 | 0.34 |
| ▸ | LTA4H | P09960 | 2/20 | 0.34 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.33 |
| ▸ | ADH4 | P08319 | 1/20 | 0.33 |
| ▸ | KIF11 | P52732 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.32 |
| ▸ | CASR | P41180 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | RRM1 | P23921 | 1/20 | 0.31 |
| ▸ | GFPT1 | Q06210 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23451025 | 0.89 | ADH1B (0.41) | ADH1BADH1AADH7ADH1CLTA4H | |
| SCHEMBL27686000 | 0.80 | P2RY10 (0.36) | LTA4HKIF11CA1CA2SLC1A1 | |
| SCHEMBL13662314 | 0.80 | P2RY10 (0.36) | LTA4HKIF11CA1CA2SLC1A1 | |
| SCHEMBL8309760 | 0.80 | ADH1B (0.44) | ADH1BADH1AADH7ADH1CDPP7 | |
| SCHEMBL28540932 | 0.79 | MAPT (0.37) | — | |
| SCHEMBL28537547 | 0.79 | MAPT (0.37) | — | |
| SCHEMBL11776470 | 0.79 | SMN1; SMN2 (0.42) | LTA4HKIF11CA1CA2SLC1A1 | |
| SCHEMBL20041853 | 0.78 | ADH1B (0.38) | ADH1BADH1AADH7ADH1CEPHX1 | |
| SCHEMBL28144230 | 0.78 | GSR (0.46) | SLC1A1 | |
| SCHEMBL1301293 | 0.77 | MAPT (0.37) | LTA4HDPP7CA1CA2SLC1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5922741-A | 5-aminopyrazoles useful as tyrosine kinase inhibitors | CELLTECH THERAPEUTICS LTD. (GB) | 1999-07-13 | — | — | US | disclosed |
| EP-0906286-A1 | 5-AMINOPYRAZOLES USEFUL AS SELECTIVE INHIBITORS OF THE PROTEIN TYROSINE KINASE P56ICK | CELLTECH THERAPEUTICS LIMITED (GB) | 1999-04-07 | — | — | EP | disclosed |
| WO-1997040019-A1 | 5-AMINOPYRAZOLES USEFUL AS SELECTIVE INHIBITORS OF THE PROTEIN TYROSINE KINASE P56ICK | CELLTECH THERAPEUTICS LIMITED (GB) | 1997-10-30 | — | — | WO | disclosed |