Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.47 |
| ▸ | IKBKB | O14920 | 10/20 | 0.46 |
| ▸ | CHUK | O15111 | 8/20 | 0.46 |
| ▸ | IKBKG | Q9Y6K9 | 7/20 | 0.46 |
| ▸ | CDK1 | P06493 | 2/20 | 0.46 |
| ▸ | CDK2 | P24941 | 2/20 | 0.46 |
| ▸ | AKT1 | P31749 | 1/20 | 0.46 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.46 |
| ▸ | CDK9 | P50750 | 1/20 | 0.46 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.46 |
| ▸ | NOS3 | P29474 | 1/20 | 0.45 |
| ▸ | NOS1 | P29475 | 1/20 | 0.45 |
| ▸ | NOS2 | P35228 | 1/20 | 0.45 |
| ▸ | CFTR | P13569 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4074601 | 0.88 | IKBKB (0.50) | PIK3CAPIK3CBPIK3CGIKBKBCHUK | |
| SCHEMBL14021077 | 0.86 | CDK2 (0.58) | PIK3CAPIK3CBPIK3CGIKBKBCHUK | |
| SCHEMBL14063766 | 0.85 | IKBKB (0.51) | PIK3CAPIK3CBPIK3CGIKBKBCHUK | |
| SCHEMBL8316042 | 0.85 | IKBKB (0.49) | PIK3CAPIK3CBPIK3CGIKBKBCHUK | |
| SCHEMBL8312581 | 0.85 | CDK1 (0.58) | PIK3CAPIK3CBPIK3CGIKBKBCHUK | |
| SCHEMBL13590857 | 0.84 | CDK1 (0.54) | PIK3CAPIK3CBPIK3CGIKBKBCHUK | |
| SCHEMBL11924743 | 0.84 | GRM5 (0.60) | PIK3CAPIK3CBPIK3CGIKBKBCHUK | |
| SCHEMBL11924740 | 0.84 | MTOR (0.51) | PIK3CAPIK3CBPIK3CGIKBKBCHUK | |
| Hydrochloric Acid SCHEMBL4071661 | 0.84 | CDK1 (0.53) | PIK3CAPIK3CBPIK3CGIKBKBCHUK | |
| SCHEMBL8254568 | 0.83 | JAK2 (0.55) | PIK3CAPIK3CBPIK3CGIKBKBCHUK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1349840-B1 | ANILINOPYRIMIDINE DERIVATIVES AS JNK PATHWAY INHIBITORS AND COMPOSITIONS AND METHODS RELATED THERETO | SIGNAL PHARM LLC (US) | 2009-03-11 | — | — | EP | disclosed |
| US-7442699-B2 | Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-10-28 | — | — | US | disclosed |
| US-7442699-B2 | Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-10-28 | — | — | US | disclosed |
| US-7429599-B2 | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-09-30 | — | — | US | disclosed |
| US-7429599-B2 | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-09-30 | — | — | US | disclosed |
| WO-2004084901-A1 | METHODS FOR TREATING OR PREVENTING AN INFLAMMATORY OR METABOLIC CONDITION BY INHIBITING JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2004-10-07 | — | — | WO | disclosed |